P12843 · IBP2_RAT

  • Protein
    Insulin-like growth factor-binding protein 2
  • Gene
    Igfbp2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Inhibits IGF-mediated growth and developmental rates (By similarity).
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentextracellular region
Cellular Componentextracellular space
Molecular Functioninsulin-like growth factor binding
Molecular Functioninsulin-like growth factor I binding
Molecular Functioninsulin-like growth factor II binding
Biological Processcellular response to hormone stimulus
Biological Processfemale pregnancy
Biological Processpositive regulation of activated T cell proliferation
Biological Processregulation of insulin-like growth factor receptor signaling pathway
Biological Processresponse to estradiol
Biological Processresponse to estrogen
Biological Processresponse to glucocorticoid
Biological Processresponse to mechanical stimulus
Biological Processresponse to nutrient
Biological Processresponse to organic cyclic compound
Biological Processresponse to retinoic acid
Biological Processresponse to steroid hormone
Biological Processresponse to xenobiotic stimulus

Keywords

Enzyme and pathway databases

    • R-RNO-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Insulin-like growth factor-binding protein 2
  • Short names
    IBP-2; IGF-binding protein 2; IGFBP-2
  • Alternative names
    • BRL-BP

Gene names

    • Name
      Igfbp2
    • Synonyms
      Igfbp-2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    P12843
  • Secondary accessions
    • Q569C7

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-34
ChainPRO_000001437335-304Insulin-like growth factor-binding protein 2
Disulfide bond40↔68
Disulfide bond43↔70
Disulfide bond51↔71
Disulfide bond59↔74
Disulfide bond82↔95
Disulfide bond89↔115
Disulfide bond206↔240
Disulfide bond251↔262
Disulfide bond264↔285

Post-translational modification

O-glycosylated.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

In adults, expressed in brain, testes, ovaries, and kidney. Expression in the adult liver is barely detectable.

Developmental stage

Predominantly expressed at fetal stages with highest expression in fetal liver. Also expressed in fetal kidney, intestine and lung, as well as muscle, heart and stomach.

Gene expression databases

Interaction

Subunit

Binds IGF2 more than IGF1.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, motif.

TypeIDPosition(s)Description
Domain36-118IGFBP N-terminal
Domain203-285Thyroglobulin type-1
Motif280-282Cell attachment site

Domain

The C-terminus is required for IGF-binding and growth inhibition.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    304
  • Mass (Da)
    32,855
  • Last updated
    2007-05-01 v3
  • Checksum
    8558B7E2C9152B9F
MLPRLGGPALPLLLPSLLLLLLLGAGGCGPGVRAEVLFRCPPCTPERLAACGPPPDAPCAELVREPGCGCCSVCARQEGEACGVYIPRCAQTLRCYPNPGSELPLKALVTGAGTCEKRRVGATPQQVADSEDDHSEGGLVENHVDGTMNMLGGSSAGRKPPKSGMKELAVFREKVNEQHRQMGKGAKHLSLEEPKKLRPPPARTPCQQELDQVLERISTMRLPDDRGPLEHLYSLHIPNCDKHGLYNLKQCKMSLNGQRGECWCVNPNTGKPIQGAPTIRGDPECHLFYNEQQENDGAHAQRVQ

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict298in Ref. 1; AAA40829

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
J04486
EMBL· GenBank· DDBJ
AAA40829.1
EMBL· GenBank· DDBJ
mRNA
M31672
EMBL· GenBank· DDBJ
AAA41381.1
EMBL· GenBank· DDBJ
mRNA
BC092570
EMBL· GenBank· DDBJ
AAH92570.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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