P12843 · IBP2_RAT
- ProteinInsulin-like growth factor-binding protein 2
- GeneIgfbp2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids304 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Inhibits IGF-mediated growth and developmental rates (By similarity).
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Cellular Component | extracellular region | |
Cellular Component | extracellular space | |
Molecular Function | insulin-like growth factor binding | |
Molecular Function | insulin-like growth factor I binding | |
Molecular Function | insulin-like growth factor II binding | |
Biological Process | cellular response to hormone stimulus | |
Biological Process | female pregnancy | |
Biological Process | positive regulation of activated T cell proliferation | |
Biological Process | regulation of insulin-like growth factor receptor signaling pathway | |
Biological Process | response to estradiol | |
Biological Process | response to estrogen | |
Biological Process | response to glucocorticoid | |
Biological Process | response to mechanical stimulus | |
Biological Process | response to nutrient | |
Biological Process | response to organic cyclic compound | |
Biological Process | response to retinoic acid | |
Biological Process | response to steroid hormone | |
Biological Process | response to xenobiotic stimulus |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameInsulin-like growth factor-binding protein 2
- Short namesIBP-2; IGF-binding protein 2; IGFBP-2
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionP12843
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-34 | |||||
Sequence: MLPRLGGPALPLLLPSLLLLLLLGAGGCGPGVRA | ||||||
Chain | PRO_0000014373 | 35-304 | Insulin-like growth factor-binding protein 2 | |||
Sequence: EVLFRCPPCTPERLAACGPPPDAPCAELVREPGCGCCSVCARQEGEACGVYIPRCAQTLRCYPNPGSELPLKALVTGAGTCEKRRVGATPQQVADSEDDHSEGGLVENHVDGTMNMLGGSSAGRKPPKSGMKELAVFREKVNEQHRQMGKGAKHLSLEEPKKLRPPPARTPCQQELDQVLERISTMRLPDDRGPLEHLYSLHIPNCDKHGLYNLKQCKMSLNGQRGECWCVNPNTGKPIQGAPTIRGDPECHLFYNEQQENDGAHAQRVQ | ||||||
Disulfide bond | 40↔68 | |||||
Sequence: CPPCTPERLAACGPPPDAPCAELVREPGC | ||||||
Disulfide bond | 43↔70 | |||||
Sequence: CTPERLAACGPPPDAPCAELVREPGCGC | ||||||
Disulfide bond | 51↔71 | |||||
Sequence: CGPPPDAPCAELVREPGCGCC | ||||||
Disulfide bond | 59↔74 | |||||
Sequence: CAELVREPGCGCCSVC | ||||||
Disulfide bond | 82↔95 | |||||
Sequence: CGVYIPRCAQTLRC | ||||||
Disulfide bond | 89↔115 | |||||
Sequence: CAQTLRCYPNPGSELPLKALVTGAGTC | ||||||
Disulfide bond | 206↔240 | |||||
Sequence: CQQELDQVLERISTMRLPDDRGPLEHLYSLHIPNC | ||||||
Disulfide bond | 251↔262 | |||||
Sequence: CKMSLNGQRGEC | ||||||
Disulfide bond | 264↔285 | |||||
Sequence: CVNPNTGKPIQGAPTIRGDPEC |
Post-translational modification
O-glycosylated.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
In adults, expressed in brain, testes, ovaries, and kidney. Expression in the adult liver is barely detectable.
Developmental stage
Predominantly expressed at fetal stages with highest expression in fetal liver. Also expressed in fetal kidney, intestine and lung, as well as muscle, heart and stomach.
Gene expression databases
Interaction
Structure
Family & Domains
Features
Showing features for domain, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 36-118 | IGFBP N-terminal | ||||
Sequence: VLFRCPPCTPERLAACGPPPDAPCAELVREPGCGCCSVCARQEGEACGVYIPRCAQTLRCYPNPGSELPLKALVTGAGTCEKR | ||||||
Domain | 203-285 | Thyroglobulin type-1 | ||||
Sequence: RTPCQQELDQVLERISTMRLPDDRGPLEHLYSLHIPNCDKHGLYNLKQCKMSLNGQRGECWCVNPNTGKPIQGAPTIRGDPEC | ||||||
Motif | 280-282 | Cell attachment site | ||||
Sequence: RGD |
Domain
The C-terminus is required for IGF-binding and growth inhibition.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length304
- Mass (Da)32,855
- Last updated2007-05-01 v3
- Checksum8558B7E2C9152B9F
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 298 | in Ref. 1; AAA40829 | ||||
Sequence: A → V |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
J04486 EMBL· GenBank· DDBJ | AAA40829.1 EMBL· GenBank· DDBJ | mRNA | ||
M31672 EMBL· GenBank· DDBJ | AAA41381.1 EMBL· GenBank· DDBJ | mRNA | ||
BC092570 EMBL· GenBank· DDBJ | AAH92570.1 EMBL· GenBank· DDBJ | mRNA |