Phosphorylation of ssDNA endodeoxyribonuclease SAE2 (Sae2)does not affect its overall capacity to interact with Mre11-Rad50-Xrs2 (MRX) it controls the specific physical and functional interaction with the MRX subunit Rad50 which is a prerequisite for the regulation of the Mre11 nuclease.
Xrs2 dependent and independent functions of the Mre11-Rad50 complex orchestrating the cellular response to double-strand DNA breaks have been described.
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