P12723 · R1AB_IBVK

Function

function

The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products.
NendoU is a Mn2+-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.

Features

Showing features for active site, site.

152150100150200250300350400450500
Type
IDPosition(s)Description
Active site104
Active site119
Active site159
Site219-220Cleavage; by 3CL-PRO
Active site263
Active site347
Active site391
Active site424

GO annotations

AspectTerm
Molecular Functionendonuclease activity
Molecular FunctionmRNA (nucleoside-2'-O-)-methyltransferase activity
Molecular FunctionRNA nuclease activity
Biological Processmethylation
Biological Processviral translational frameshifting

Keywords

Names & Taxonomy

Protein names

Gene names

    • Name
      rep
    • ORF names
      1a-1b

Organism names

Accessions

  • Primary accession
    P12723

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000374321-219Uridylate-specific endoribonuclease
ChainPRO_0000037433220-521Putative 2'-O-methyl transferase

Structure

3D structure databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-58AV-Nsp11N/CoV-Nsp15M
Domain75-216NendoU
Domain219-518Nidovirus-type SAM-dependent 2'-O-MTase

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Fragment

This entry describes 2 isoforms produced by Ribosomal frameshifting.

P12723-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    Replicase polyprotein 1ab
  • Synonyms
    pp1ab
  • Note
    Produced by -1 ribosomal frameshifting at the 1a-1b genes boundary.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    521
  • Mass (Da)
    58,200
  • Last updated
    1989-10-01 v1
  • Checksum
    B979E3D32BCAFB74
GGGGQSFLAADNAVLVSTQCYKRHSYVEIPSNLLVQNGMSLKDGANLYVYKRVNGAFVTLPNTLNTQGRSYETFEPRSDVERDFLDMSEEDFVEKYGKDLGLQHILYGEVDKPQLGGLHTVIGMYRLLRANKLNAKSVTNSDSDVMQNYFVLADNGSYKQVCTVVDLLLDDFLELLRNILNEYGTNKSKVVTVSIDYHSINFMTWFEDGSIKTCYPQLQSAWTCGYNMPELYKVQNCVMEPCNIPNYGVGITLPSGIMMNVAKYTQLCQYLSKTTVCVPHNMRVMHFGAGSDKGVAPGSTVLKQWLPEGTLLVDTDIVDYVSDAHVSVLSDCNKYKTEHKFDLVISDMYTDNDSKRKHGGVIANNGNDDVFIYLSSFLRNNLALGGSFAVKLTETSWHESLYDIAQDCAWWTMFCTAVNASSSEAFLIGVNYLGASVKVKVSGKTLHANYIFWRNCNYLQTSAYSIFDVAKFDLRLKATPVVNLKTEQKTDLVFNLIKCGKLLVRDVGNTSFTSDSFVCTM

P12723-2

  • Name
    Replicase polyprotein 1a
  • Synonyms
    pp1a, ORF1a polyprotein
  • Note
    Produced by -1 ribosomal frameshifting at the 1a-1b genes boundary.
  • See also
    sequence in UniParc or sequence clusters in UniRef

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M21515
EMBL· GenBank· DDBJ
AAA66577.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

Disclaimer

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