P12723 · R1AB_IBVK
- ProteinReplicase polyprotein 1ab
- Generep
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids521 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products.
NendoU is a Mn2+-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.
Features
Showing features for active site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 104 | ||||
Active site | 119 | ||||
Active site | 159 | ||||
Site | 219-220 | Cleavage; by 3CL-PRO | |||
Active site | 263 | ||||
Active site | 347 | ||||
Active site | 391 | ||||
Active site | 424 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | endonuclease activity | |
Molecular Function | mRNA (nucleoside-2'-O-)-methyltransferase activity | |
Molecular Function | RNA nuclease activity | |
Biological Process | methylation | |
Biological Process | viral translational frameshifting |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameReplicase polyprotein 1ab
- Short namespp1ab
- Alternative names
- Cleaved into 2 chains
Gene names
Organism names
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Nidovirales > Cornidovirineae > Coronaviridae > Orthocoronavirinae > Gammacoronavirus > Igacovirus > Avian coronavirus
- Virus hosts
Accessions
- Primary accessionP12723
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000037432 | 1-219 | Uridylate-specific endoribonuclease | ||
Chain | PRO_0000037433 | 220-521 | Putative 2'-O-methyl transferase | ||
Sequence & Isoform
- Sequence statusFragment
This entry describes 2 isoforms produced by Ribosomal frameshifting.
P12723-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameReplicase polyprotein 1ab
- Synonymspp1ab
- NoteProduced by -1 ribosomal frameshifting at the 1a-1b genes boundary.
- Length521
- Mass (Da)58,200
- Last updated1989-10-01 v1
- ChecksumB979E3D32BCAFB74
P12723-2
- NameReplicase polyprotein 1a
- Synonymspp1a, ORF1a polyprotein
- NoteProduced by -1 ribosomal frameshifting at the 1a-1b genes boundary.
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Keywords
- Coding sequence diversity
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M21515 EMBL· GenBank· DDBJ | AAA66577.1 EMBL· GenBank· DDBJ | Genomic RNA |