P12656 · TSHB_MOUSE

  • Protein
    Thyrotropin subunit beta
  • Gene
    Tshb
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Indispensable for the control of thyroid structure and metabolism.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentextracellular space
Molecular Functionhormone activity
Biological ProcessG protein-coupled receptor signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Thyrotropin subunit beta
  • Alternative names
    • Thyroid-stimulating hormone subunit beta (TSH-B; TSH-beta)
    • Thyrotropin beta chain

Gene names

    • Name
      Tshb

Organism names

  • Taxonomic identifier
  • Strain
    • LAF1
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P12656

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation, propeptide.

TypeIDPosition(s)Description
Signal1-20
ChainPRO_000001175021-132Thyrotropin subunit beta
Disulfide bond22↔72
Disulfide bond36↔87
Disulfide bond39↔125
Glycosylation43N-linked (GlcNAc...) asparagine
Disulfide bond47↔103
Disulfide bond51↔105
Disulfide bond108↔115
PropeptidePRO_0000011751133-138

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    138
  • Mass (Da)
    15,373
  • Last updated
    1989-10-01 v1
  • Checksum
    44386FF3E17C5BEB
MSAAVLLSVLFALACGQAASFCIPTEYTMYVDRRECAYCLTINTTICAGYCMTRDINGKLFLPKYALSQDVCTYRDFIYRTVEIPGCPHHVTPYFSFPVAVSCKCGKCNTDNSDCIHEAVRTNYCTKPQSFYLGGFSV

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
E9Q4F3E9Q4F3_MOUSETshb138

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M20537
EMBL· GenBank· DDBJ
AAA40494.1
EMBL· GenBank· DDBJ
Genomic DNA
M20536
EMBL· GenBank· DDBJ
AAA40494.1
EMBL· GenBank· DDBJ
Genomic DNA
M22740
EMBL· GenBank· DDBJ
AAA40493.1
EMBL· GenBank· DDBJ
Genomic DNA
M35719
EMBL· GenBank· DDBJ
AAA37307.1
EMBL· GenBank· DDBJ
mRNA
M35720
EMBL· GenBank· DDBJ
AAA37308.1
EMBL· GenBank· DDBJ
mRNA
M35721
EMBL· GenBank· DDBJ
AAA37309.1
EMBL· GenBank· DDBJ
mRNA
M35723
EMBL· GenBank· DDBJ
AAA37310.1
EMBL· GenBank· DDBJ
mRNA
M54943
EMBL· GenBank· DDBJ
AAA40492.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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