P12291 · TRPA_CAUVC
- ProteinTryptophan synthase alpha chain
- GenetrpA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids275 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
Catalytic activity
- (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan
Pathway
Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 51 | Proton acceptor | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | tryptophan synthase activity |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTryptophan synthase alpha chain
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Caulobacterales > Caulobacteraceae > Caulobacter
Accessions
- Primary accessionP12291
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000098765 | 1-275 | Tryptophan synthase alpha chain | |||
Sequence: MTKDRIDRRFAALKAENRAGFVTYVMAGDPDAATTLSVLKGLPAAGADLIELGFPFSDPMAEGPTIQRAAQRGLKSGMTLQGTLDLVAAFREGDQDTPIILMGYLNPVLNKGFETFAALAAKAGVDGLIIVDCPPEEADPLSDALEAEGIALIRLAAPTTDDARLPMVVRRTSGFVYYVSVAGVTGVKSADAADVAPAVERLRKASGLPVAVGFGIRTPDQAAAVAKVADAAVVGSALVDEIESAAQLNENVTEKVLLKASELAKAVRSARVGTK |
Interaction
Structure
Sequence
- Sequence statusComplete
- Length275
- Mass (Da)28,520
- Last updated1989-10-01 v1
- ChecksumC275DA90C80B271F
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M19129 EMBL· GenBank· DDBJ | AAA23058.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE005673 EMBL· GenBank· DDBJ | AAK25505.1 EMBL· GenBank· DDBJ | Genomic DNA |