P12252 · PDE4B_DROME
- Protein3',5'-cyclic-AMP phosphodiesterase
- Genednc
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1070 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Vital for female fertility. Required for learning/memory
Catalytic activity
- 3',5'-cyclic AMP + H2O = AMP + H+This reaction proceeds in the forward direction.
Cofactor
Pathway
Features
Showing features for active site, binding site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 732 | Proton donor | ||||
Sequence: H | ||||||
Binding site | 732-736 | 3',5'-cyclic AMP (UniProtKB | ChEBI) | ||||
Sequence: HNSLH | ||||||
Binding site | 736 | a divalent metal cation 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 772 | a divalent metal cation 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 773 | 3',5'-cyclic AMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 773 | a divalent metal cation 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 773 | a divalent metal cation 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 890 | 3',5'-cyclic AMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 890 | a divalent metal cation 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Site | 893 | Binds AMP, but not cAMP | ||||
Sequence: N | ||||||
Binding site | 941 | 3',5'-cyclic AMP (UniProtKB | ChEBI) | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Cellular Component | perinuclear region of cytoplasm | |
Cellular Component | synapse | |
Molecular Function | 3',5'-cyclic-AMP phosphodiesterase activity | |
Molecular Function | 3',5'-cyclic-GMP phosphodiesterase activity | |
Molecular Function | metal ion binding | |
Biological Process | anesthesia-resistant memory | |
Biological Process | associative learning | |
Biological Process | axon extension | |
Biological Process | cAMP catabolic process | |
Biological Process | cAMP-mediated signaling | |
Biological Process | chemical synaptic transmission | |
Biological Process | circadian rhythm | |
Biological Process | conditioned taste aversion | |
Biological Process | courtship behavior | |
Biological Process | learning | |
Biological Process | mating behavior | |
Biological Process | memory | |
Biological Process | nonassociative learning | |
Biological Process | olfactory learning | |
Biological Process | regulation of protein kinase A signaling | |
Biological Process | short-term memory | |
Biological Process | thermosensory behavior |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3',5'-cyclic-AMP phosphodiesterase
- EC number
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionP12252
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000023342 | 1-1070 | 3',5'-cyclic-AMP phosphodiesterase | |||
Sequence: MSQESNGGPAAGGGAAAAPPPPPQYIITTPSEVDPDEVRSMADLELGSPEKQVQVQSQKFSSTSSTTKVATHSFSMSSSAGTTGQQSKQDSAQQIQQLQQLQQLQQLQQQQQQQQSQRIISSSTRSQSLQSSTIVGEATTITSGAAQILSASAAASLAQQLKAQSSTSIITSSEQRTSTSTSSSSSTRYIASGSSNLAGGNSNSASSASSKTRFQSFLQQPEGAHGFLTAHQKHVRQFVRSTSAHSEAAAGVAGARAEKCIRSASTQIDDASVAGVVESAGNLTDSSATGGSMQLSMSKLGLQQSSSILISKSAETIEMKSSSAGMRTQLTLSGGFLAPPGNRKITILSPIHAPPGLHDMLKRAQGRSPLSPRISFPGSDSDLFGFDVENGQGARSPLEGGSPSAGLVLQNLPQRRESFLYRSDSDFEMSPKSMSRNSSIASERFKEQEASILVDRSHGEDLIVTPFAQILASLRSVRNNLLSLTNVPASNKSRRPNQSSSASRSGNPPGAPLSQGEEAYTRLATDTIEELDWCLDQLETIQTHRSVSDMASLKFKRMLNKELSHFSESSRSGNQISEYICSTFLDKQQEFDLPSLRVEDNPELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLSHTNSFTGERLPTFGVETPRENELGTLLGELDTWGIQIFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERESGMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEENRDYYQSMIPPSPPPSGVDENPQEDRIRFQVTLEESDQENLAELEEGDESGGESTTTGTTGTTAASALSGAGGGGGGGGGMAPRTGGCQNQPQHGGM |
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-91 | Disordered | ||||
Sequence: MSQESNGGPAAGGGAAAAPPPPPQYIITTPSEVDPDEVRSMADLELGSPEKQVQVQSQKFSSTSSTTKVATHSFSMSSSAGTTGQQSKQDS | ||||||
Compositional bias | 50-91 | Polar residues | ||||
Sequence: EKQVQVQSQKFSSTSSTTKVATHSFSMSSSAGTTGQQSKQDS | ||||||
Region | 166-215 | Disordered | ||||
Sequence: STSIITSSEQRTSTSTSSSSSTRYIASGSSNLAGGNSNSASSASSKTRFQ | ||||||
Compositional bias | 487-510 | Polar residues | ||||
Sequence: VPASNKSRRPNQSSSASRSGNPPG | ||||||
Region | 487-516 | Disordered | ||||
Sequence: VPASNKSRRPNQSSSASRSGNPPGAPLSQG | ||||||
Compositional bias | 615-629 | Polar residues | ||||
Sequence: SAGQYARSRSPRGPP | ||||||
Region | 615-653 | Disordered | ||||
Sequence: SAGQYARSRSPRGPPMSQISGVKRPLSHTNSFTGERLPT | ||||||
Compositional bias | 636-651 | Polar residues | ||||
Sequence: VKRPLSHTNSFTGERL | ||||||
Domain | 656-985 | PDEase | ||||
Sequence: VETPRENELGTLLGELDTWGIQIFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERESGMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEENRDYYQSMIPPS | ||||||
Region | 1007-1070 | Disordered | ||||
Sequence: EESDQENLAELEEGDESGGESTTTGTTGTTAASALSGAGGGGGGGGGMAPRTGGCQNQPQHGGM | ||||||
Compositional bias | 1024-1040 | Polar residues | ||||
Sequence: GGESTTTGTTGTTAASA |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 12 isoforms produced by Alternative splicing & Alternative initiation.
P12252-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameII
- SynonymsI, J
- NoteProduced by alternative initiation at Met-429 of isoform II.
- Length1,070
- Mass (Da)115,079
- Last updated2005-08-16 v4
- Checksum50A63BF7BCC8EDD9
P12252-3
- NameIV
- SynonymsA
P12252-4
- NameV
- SynonymsC
- Differences from canonical
- 444-456: Missing
P12252-5
- NameVI
- SynonymsD
- Differences from canonical
- 493-494: Missing
P12252-6
- NameVII
- SynonymsL
- Differences from canonical
- 1-549: Missing
P12252-7
- NameIII
- SynonymsE, P
- NoteProduced by alternative initiation at Met-429 of isoform II.
- Differences from canonical
- 1-428: Missing
P12252-8
- NameR
- SynonymsQ
- NoteProduced by alternative initiation at Met-429 of isoform II.
P12252-9
- NameU
- SynonymsT
Q9W4T4-1
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- NameI
- SynonymsB, S
- NoteProduced by alternative initiation at Met-429 of isoform II.
Q8IRU4-1
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- NameF
- NoteProduced by alternative initiation at Met-429 of isoform II.
Q9W4S9-2
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- NameG
Q9W4S9-1
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- NameN
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Sequence caution
Features
Showing features for alternative sequence, compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_054956 | 1-355 | in isoform U | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_054955 | 1-367 | in isoform R | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_004585 | 1-369 | in isoform IV | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_018826 | 1-428 | in isoform III | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_004587 | 1-549 | in isoform VII | |||
Sequence: Missing | ||||||
Compositional bias | 50-91 | Polar residues | ||||
Sequence: EKQVQVQSQKFSSTSSTTKVATHSFSMSSSAGTTGQQSKQDS | ||||||
Alternative sequence | VSP_054957 | 356-385 | in isoform U | |||
Sequence: GLHDMLKRAQGRSPLSPRISFPGSDSDLFG → MQAEQGSIGDLQKYHSRYLKNRRHTLANVR | ||||||
Alternative sequence | VSP_054958 | 368-385 | in isoform R | |||
Sequence: SPLSPRISFPGSDSDLFG → MVCSFCCCCYNFRNSPSS | ||||||
Alternative sequence | VSP_004586 | 370-385 | in isoform IV | |||
Sequence: LSPRISFPGSDSDLFG → MVCSFCCCCYNFRNSP | ||||||
Alternative sequence | VSP_004588 | 444-456 | in isoform V | |||
Sequence: Missing | ||||||
Compositional bias | 487-510 | Polar residues | ||||
Sequence: VPASNKSRRPNQSSSASRSGNPPG | ||||||
Alternative sequence | VSP_004589 | 493-494 | in isoform VI | |||
Sequence: Missing | ||||||
Compositional bias | 615-629 | Polar residues | ||||
Sequence: SAGQYARSRSPRGPP | ||||||
Compositional bias | 636-651 | Polar residues | ||||
Sequence: VKRPLSHTNSFTGERL | ||||||
Sequence conflict | 958 | in Ref. 1; CAA38960 and 2; AAC34201 | ||||
Sequence: D → S | ||||||
Compositional bias | 1024-1040 | Polar residues | ||||
Sequence: GGESTTTGTTGTTAASA | ||||||
Sequence conflict | 1027 | in Ref. 1; CAA38960 and 2; AAC34201 | ||||
Sequence: S → T | ||||||
Sequence conflict | 1042-1043 | in Ref. 1; CAA38960 and 2; AAC34201 | ||||
Sequence: SG → R |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X55167 EMBL· GenBank· DDBJ | CAA38960.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
X55168 EMBL· GenBank· DDBJ | CAA38960.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
X55169 EMBL· GenBank· DDBJ | CAA38960.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
X55170 EMBL· GenBank· DDBJ | CAA38960.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
X55171 EMBL· GenBank· DDBJ | CAA38960.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
X55172 EMBL· GenBank· DDBJ | CAA38960.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
X55173 EMBL· GenBank· DDBJ | CAA38960.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
X55174 EMBL· GenBank· DDBJ | CAA38960.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
X55175 EMBL· GenBank· DDBJ | CAA38960.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
M14982 EMBL· GenBank· DDBJ | AAC34201.1 EMBL· GenBank· DDBJ | Unassigned DNA | Different initiation | |
M14978 EMBL· GenBank· DDBJ | AAC34201.1 EMBL· GenBank· DDBJ | Unassigned DNA | Different initiation | |
M14979 EMBL· GenBank· DDBJ | AAC34201.1 EMBL· GenBank· DDBJ | Unassigned DNA | Different initiation | |
M14980 EMBL· GenBank· DDBJ | AAC34201.1 EMBL· GenBank· DDBJ | Unassigned DNA | Different initiation | |
M14981 EMBL· GenBank· DDBJ | AAC34201.1 EMBL· GenBank· DDBJ | Unassigned DNA | Different initiation | |
AE014298 EMBL· GenBank· DDBJ | AAF45861.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014298 EMBL· GenBank· DDBJ | AAF45862.3 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014298 EMBL· GenBank· DDBJ | AAF45865.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014298 EMBL· GenBank· DDBJ | AAN09600.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014298 EMBL· GenBank· DDBJ | AAN09601.3 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014298 EMBL· GenBank· DDBJ | AAN09602.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014298 EMBL· GenBank· DDBJ | AAN09604.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014298 EMBL· GenBank· DDBJ | AAN09607.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014298 EMBL· GenBank· DDBJ | AGB95048.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014298 EMBL· GenBank· DDBJ | AGB95049.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL121800 EMBL· GenBank· DDBJ | CAD24781.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AY119511 EMBL· GenBank· DDBJ | AAM50165.1 EMBL· GenBank· DDBJ | mRNA |