P12000 · DNLI1_SCHPO

Function

function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

Catalytic activity

  • ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.
    EC:6.5.1.1 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for site, binding site, active site.

1768100200300400500600700
TypeIDPosition(s)Description
Site165Interaction with target DNA
Binding site414ATP (UniProtKB | ChEBI)
Active site416N6-AMP-lysine intermediate
Binding site421ATP (UniProtKB | ChEBI)
Binding site437ATP (UniProtKB | ChEBI)
Site438Interaction with target DNA
Binding site469Mg2+ 1 (UniProtKB | ChEBI)
Binding site568Mg2+ 2 (UniProtKB | ChEBI)
Binding site573ATP (UniProtKB | ChEBI)
Binding site587ATP (UniProtKB | ChEBI)
Binding site593ATP (UniProtKB | ChEBI)
Site619Interaction with target DNA
Site644Interaction with target DNA

GO annotations

AspectTerm
Cellular Componentmitochondrion
Cellular Componentnuclear replication fork
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA ligase (ATP) activity
Molecular FunctionDNA ligase activity
Molecular Functionmetal ion binding
Biological Processbase-excision repair
Biological Processcell division
Biological ProcessDNA biosynthetic process
Biological ProcessDNA ligation
Biological ProcessDNA recombination
Biological ProcessDNA repair
Biological Processlagging strand elongation
Biological Processmitochondrial DNA metabolic process
Biological Processnucleotide-excision repair
Biological ProcessOkazaki fragment processing involved in mitotic DNA replication

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA ligase 1
  • EC number
  • Alternative names
    • DNA ligase I
    • Polydeoxyribonucleotide synthase [ATP] 1

Gene names

    • Name
      cdc17
    • ORF names
      SPAC20G8.01, SPAC57A10.13c

Organism names

Accessions

  • Primary accession
    P12000

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000595851-768DNA ligase 1

Proteomic databases

PTM databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region42-139Disordered
Compositional bias55-96Basic and acidic residues
Compositional bias97-123Polar residues
Region309-318Interaction with target DNA
Region490-492Interaction with target DNA

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    768
  • Mass (Da)
    86,581
  • Last updated
    1989-10-01 v1
  • Checksum
    6783FF3DDC675F31
MRTVFSQIPRFKQVNQYIRMSTRQSDISNFFISSASHKSEHVEVSQSSSDSKNVDGRSTSEKRKVESVKLVDESKHNNHDDTGTQNVERENNIVSEAKKQKTLGSSSSSSDAVSSNNDSGASTPIPLPIKEPPLESNARNDKLKGHATFAEMVKAFTKIENTSKRLEIIDIMGTYFFGILRDHPSDLLACVYLSINKLGPDYSGLELGIGESIIMKAIGESTGQTLQQIKLSFHKVGDLGLVAQTSRQNQPTMFKPAALTIPFLFDSLKKIAQMSGNQSQNRKIGVIKRLLSSCEGAEPKYLIRALEGKLRLQLAEKTILVALANATAQYHADKNGEKLSQQDRIEGEQILRDVYCQLPSYDLIVPHLIEHGLGTLRETCKLTPGIPTKPMLAKPTKQISEVLNTFDQAAFTCEYKYDGERAQVHFTEDGKFYVFSRNSENMSVRYPDISVSVSKWKKPDARSFILDCEAVGWDRDENKILPFQKLATRKRKDVKIGDIKVRACLFAFDILYLNGQPLLETPLNERRKLLYSMFQPSTGDFTFAKHSDQKSIESIEEFLEESVKDSCEGLMVKMLEGPDSHYEPSKRSRHWLKVKKDYLSGVGDSLDLIVIGAYYGKGKRTSVYGAFLLGCYDPDTETVQSICKLGTGFSEEHLETFYNQLKDIVISKKKDFYAHSDVPAHQPDVWFEPKYLWEVLAADLSLSPVYKAAIGYVQEDKGISLRFPRFIRIREDKSWEDATTSEQVSEFYRSQVAYSQKEKEGSPAAEDY

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias55-96Basic and acidic residues
Compositional bias97-123Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X05107
EMBL· GenBank· DDBJ
CAA28754.1
EMBL· GenBank· DDBJ
Genomic DNA
CU329670
EMBL· GenBank· DDBJ
CAB08176.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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