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P11956 · MT2_DROME

Function

function

This protein binds cations of several transition elements. Thought to be involved in metal ion homeostasis.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functioncopper ion binding
Molecular Functionmetal ion binding
Biological Processcellular detoxification of metal ion
Biological Processresponse to metal ion

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Metallothionein-2
  • Short names
    MT-2
  • Alternative names
    • Metallothionein B

Gene names

    • Name
      MtnB
    • Synonyms
      Mto
    • ORF names
      CG4312

Organism names

  • Taxonomic identifier
  • Strains
    • Oregon-R
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    P11956
  • Secondary accessions
    • Q1ECC1
    • Q9VDM2

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for modified residue, chain.

Type
IDPosition(s)Description
Modified residue1Blocked amino end (Met)
ChainPRO_00001973551-43Metallothionein-2

Proteomic databases

Expression

Induction

Strongly induced by cadmium, copper and mercury.

Developmental stage

Expressed predominantly in embryonic and larval stages.

Gene expression databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntAct
BINARY P11956betaG Q1WWB72EBI-88468, EBI-130849
BINARY P11956Prx2 Q9V3P02EBI-88468, EBI-82319

Protein-protein interaction databases

Family & Domains

Domain

All cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    43
  • Mass (Da)
    4,525
  • Last updated
    1989-10-01 v1
  • MD5 Checksum
    23158AE6E54811D8771768E38C6DF4E7
MVCKGCGTNCQCSAQKCGDNCACNKDCQCVCKNGPKDQCCSNK

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0B4LHD1A0A0B4LHD1_DROMEMtnB43

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M16250
EMBL· GenBank· DDBJ
AAA28683.1
EMBL· GenBank· DDBJ
mRNA
X52098
EMBL· GenBank· DDBJ
CAA36318.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014297
EMBL· GenBank· DDBJ
AAF55768.1
EMBL· GenBank· DDBJ
Genomic DNA
BT025813
EMBL· GenBank· DDBJ
ABF85713.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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