P11956 · MT2_DROME
- ProteinMetallothionein-2
- GeneMtnB
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
This protein binds cations of several transition elements. Thought to be involved in metal ion homeostasis.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | copper ion binding | |
Molecular Function | metal ion binding | |
Biological Process | cellular detoxification of metal ion | |
Biological Process | response to metal ion |
Keywords
- Ligand
Names & Taxonomy
Protein names
- Recommended nameMetallothionein-2
- Short namesMT-2
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionP11956
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for modified residue, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Modified residue | 1 | Blocked amino end (Met) | |||
Chain | PRO_0000197355 | 1-43 | Metallothionein-2 | ||
Proteomic databases
Expression
Induction
Strongly induced by cadmium, copper and mercury.
Developmental stage
Expressed predominantly in embryonic and larval stages.
Gene expression databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | P11956 | betaG Q1WWB7 | 2 | EBI-88468, EBI-130849 | |
BINARY | P11956 | Prx2 Q9V3P0 | 2 | EBI-88468, EBI-82319 |
Protein-protein interaction databases
Structure
Family & Domains
Domain
All cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.
Sequence similarities
Belongs to the metallothionein superfamily. Type 5 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length43
- Mass (Da)4,525
- Last updated1989-10-01 v1
- MD5 Checksum23158AE6E54811D8771768E38C6DF4E7
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0B4LHD1 | A0A0B4LHD1_DROME | MtnB | 43 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M16250 EMBL· GenBank· DDBJ | AAA28683.1 EMBL· GenBank· DDBJ | mRNA | ||
X52098 EMBL· GenBank· DDBJ | CAA36318.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014297 EMBL· GenBank· DDBJ | AAF55768.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT025813 EMBL· GenBank· DDBJ | ABF85713.1 EMBL· GenBank· DDBJ | mRNA |