P11821 · CAP8_ADE40
- ProteinPre-hexon-linking protein VIII
- GeneL4
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids233 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Hexon-linking protein-N
Structural component of the virion that acts as a cement protein on the capsid interior and which glue the peripentonal hexons and group-of-nine hexons together.
Hexon-linking protein-C
Structural component of the virion that acts as a cement protein on the capsid interior and which glue the peripentonal hexons and group-of-nine hexons together.
Miscellaneous
All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.
Features
Showing features for site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 111-112 | Cleavage; by viral protease | |||
Site | 163-164 | Cleavage; by viral protease | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | host cell nucleus | |
Cellular Component | viral capsid | |
Molecular Function | hexon binding |
Names & Taxonomy
Protein names
- Recommended namePre-hexon-linking protein VIII
- Alternative names
- Cleaved into 2 chains
Gene names
Organism names
- Strain
- Taxonomic lineageViruses > Varidnaviria > Bamfordvirae > Preplasmiviricota > Tectiliviricetes > Rowavirales > Adenoviridae > Mastadenovirus > Human mastadenovirus F
- Virus hosts
Accessions
- Primary accessionP11821
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Hexon-linking protein-C
Note: Located on the inner side of the capsid shell. Present in 120 copies per virion.
Pre-hexon-linking protein VIII
Hexon-linking protein-N
Note: Located on the inner side of the capsid shell. Present in 120 copies per virion.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for peptide, chain, modified residue, propeptide.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Peptide | PRO_0000421400 | 1-111 | Hexon-linking protein-N | ||
Chain | PRO_0000421399 | 1-233 | Pre-hexon-linking protein VIII | ||
Modified residue | 64 | Phosphothreonine; by host | |||
Propeptide | PRO_0000036499 | 112-163 | |||
Peptide | PRO_0000036500 | 164-233 | Hexon-linking protein-C | ||
Modified residue | 180 | Phosphoserine; by host | |||
Post-translational modification
Cleaved by the viral protease during virion maturation. May cause the middle segment to be shed from the capsid.
Keywords
- PTM
Expression
Induction
Expressed in the late phase of the viral replicative cycle.
Keywords
- Developmental stage
Interaction
Subunit
Interacts with the peripentonal hexons as well as the hexons in the facets. Part of a complex composed of the core-capsid bridging protein, the endosome lysis protein VI and the hexon-linking protein VIII; these interactions bridge the virus core to the capsid.
Sequence
- Sequence statusComplete
- Length233
- Mass (Da)25,327
- Last updated1996-02-01 v2
- ChecksumD135E37D3CA6DE5C
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L19443 EMBL· GenBank· DDBJ | AAC13972.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M19316 EMBL· GenBank· DDBJ | AAA52198.1 EMBL· GenBank· DDBJ | Genomic DNA |