P11637 · QUTR_NEUCR

Function

function

Transcription repressor; part of the qa gene cluster that mediates the catabolism of quinic acid (QA) and as such, allows the use of QA as a sole carbon source (PubMed:1533844, PubMed:2525625, PubMed:3010294).
Negatively regulates transcription of the quinate utilization pathway genes, probably via binding directly to the qa-1f activator protein (PubMed:1533844, PubMed:3010294).
Probably acts as a molecular sensor that detects the presence of quinate pathway intermediates as a prerequisite for the presumed conformational changes necessary for the control of transcription regulation (PubMed:3010294).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Function3-dehydroquinate dehydratase activity
Molecular Function3-phosphoshikimate 1-carboxyvinyltransferase activity
Molecular FunctionDNA binding
Molecular Functionshikimate 3-dehydrogenase (NADP+) activity
Biological Processchorismate biosynthetic process
Biological Processquinate metabolic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Transcription factor qa-1s
  • Alternative names
    • Quinic acid degradation cluster protein 1s
    • Quinic acid utilization repressor qa-1s

Gene names

    • Name
      qa-1s
    • ORF names
      NCU06027

Organism names

Accessions

  • Primary accession
    P11637
  • Secondary accessions
    • Q7RV99

Proteomes

    • Identifier
    • Component
      Chromosome 7, Linkage Group VII

Organism-specific databases

Phenotypes & Variants

Disruption phenotype

Leads to constitutive levels of expression of the qa-2, qa-1F and qa-x genes.

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis627Impairs inducible qa cluster expression.
Mutagenesis743Impairs inducible qa cluster expression.
Mutagenesis791Leads to constitutive qa cluster expression.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000971331-918Transcription factor qa-1s

Proteomic databases

Expression

Induction

Expression is regulated by the qa-1f activator.

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region47-94Disordered
Compositional bias60-76Polar residues

Domain

The COOH-terminal region is involved in the binding to its target whereas the N-terminal region bind to the inducer.

Sequence similarities

In the N-terminal section; belongs to the shikimate kinase family.
In the 2nd section; belongs to the type-I 3-dehydroquinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    918
  • Mass (Da)
    100,580
  • Last updated
    2014-03-19 v3
  • Checksum
    67EDA399CBF098B2
MNTIPARHVGDVAARDPLPLPHISSSVASGMKRSFATMAMLYNDTGNSNDVGAHARRPPRTLSNSRSTSAHRVPLGSWSAPNSPPRRALPHHPITASFDPDASIVIAGIRGAGKSTLAIMASTAMKRKIVDLESEFHHLTGLSSSSYKKTHGPVDYGRRQIAILQNILNLHRTRAILVCSWLERDVQAMLQDFSVSNPVIYVLRDAKAIEAHLKGYDKSKVGTLLDATSTVLRRCTRFEFFNVSEENLDTHSASTSPPAVPDQRHTAPYLTLKRAERHFLKFLSLILPKGTIPFVESAFPLASVPVEQRRFTYALALPVSALLDKGVDIQELDVGVDAIEIIVDDLATSESGPTSPLGLAPHRASEISRVVGEIRRDTVIPIILHVVFPERALYEEALLALYMTYLNHALRLAPDYLTVDLGLDSGLLGQLTTVQGTTKVIGNKQLAEVNSPRWGDPSWLQAYEKAQNTGCDLVRLTRPASNPRDNTDIRQFHVAVEAVGGPRLPFIAYNTGRLGRTSMCFNEILTPVTPVPTKEDAIGLRNPAHRYLQPPLTALEATQALYSAFVHDPMKLYVFGANVGYSLSPAMHNAALKACGIPHHYKPLSTANIGTLREVISDPQFAGASVGLPFKVEIISLTHSLSRHAKAIGAVNTLIPVRHLTADGGIPDEVSMFNNISQAGAVRALYGENTDWIGIRACLRRGLSPANAVRSTSTGLVIGAGGMARAAVYAMLQLGVKKILIFNRTFANAEKLVLHFENLLVRDALPLLSTGPRSHDNTCFHIIRSRDDPLPENFKNPTMIVSCIPTHTVDNTPDPEFTVPLHWLDNPTGGIVLELDYKCLTSPLLEQTRREAHRGWVAMDGLDLLPEQGFAQFELFTGRRAPRRLMRREVLRAYPDDQAKSHTAQLQPRLNGIATQIS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias60-76Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X14603
EMBL· GenBank· DDBJ
CAA32753.1
EMBL· GenBank· DDBJ
Genomic DNA
CM002242
EMBL· GenBank· DDBJ
EAA30381.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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