P11636 · QAY_NEUCR
- ProteinMFS-type transporter qa-x
- Geneqa-y
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids537 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
MFS-type transporter; part of the qa gene cluster that mediates the catabolism of quinic acid (QA) and as such, allows the use of QA as a sole carbon source (PubMed:2525625, PubMed:6458044).
Involved in the upatke of QA (PubMed:1533844).
The qa cluster encodes 3 inducible enymes (qa-2, qa-3 and qa-4) catalyzing the first three reactions in the catabolism of quinic acid to protocatechuic acid (also known as 3,4-Dihydroxybenzoic acid) (Probable)
Involved in the upatke of QA (PubMed:1533844).
The qa cluster encodes 3 inducible enymes (qa-2, qa-3 and qa-4) catalyzing the first three reactions in the catabolism of quinic acid to protocatechuic acid (also known as 3,4-Dihydroxybenzoic acid) (Probable)
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | carbohydrate:proton symporter activity | |
Biological Process | carbohydrate transport | |
Biological Process | quinate metabolic process |
Keywords
- Biological process
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameMFS-type transporter qa-x
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Sordariomycetidae > Sordariales > Sordariaceae > Neurospora
Accessions
- Primary accessionP11636
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-26 | Cytoplasmic | ||||
Sequence: MTLLALKEDRPTPKAVYNWRVYTCAA | ||||||
Transmembrane | 27-47 | Helical; Name=1 | ||||
Sequence: IASFASCMIGYDSAFIGTTLA | ||||||
Topological domain | 48-74 | Extracellular | ||||
Sequence: LPSFTKEFDFASYTPGALALLQSNIVS | ||||||
Transmembrane | 75-95 | Helical; Name=2 | ||||
Sequence: VYQAGAFFGCLFAYATSYFLG | ||||||
Topological domain | 96-98 | Cytoplasmic | ||||
Sequence: RRK | ||||||
Transmembrane | 99-119 | Helical; Name=3 | ||||
Sequence: SLIAFSVVFIIGAAIMLAADG | ||||||
Topological domain | 120-131 | Extracellular | ||||
Sequence: QGRGIDPIIAGR | ||||||
Transmembrane | 132-152 | Helical; Name=4 | ||||
Sequence: VLAGIGVGGASNMVPIYISEL | ||||||
Topological domain | 153-160 | Cytoplasmic | ||||
Sequence: APPAVRGR | ||||||
Transmembrane | 161-181 | Helical; Name=5 | ||||
Sequence: LVGIYELGWQIGGLVGFWINY | ||||||
Topological domain | 182-195 | Extracellular | ||||
Sequence: GVNTTMAPTRSQWL | ||||||
Transmembrane | 196-216 | Helical; Name=6 | ||||
Sequence: IPFAVQLIPAGLLFLGSFWIP | ||||||
Topological domain | 217-285 | Cytoplasmic | ||||
Sequence: ESPRWLYANGKREEAMKVLCWIRNLEPTDRYIVQEVSFIDADLERYTRQVGNGFWKPFLSLKQRKVQWR | ||||||
Transmembrane | 286-306 | Helical; Name=7 | ||||
Sequence: FFLGGMLFFWQNGSGINAINY | ||||||
Topological domain | 307-327 | Extracellular | ||||
Sequence: YSPTVFRSIGITGTDTGFLTT | ||||||
Transmembrane | 328-349 | Helical; Name=8 | ||||
Sequence: GIFGVVKMVLTIIWLLWLVDLV | ||||||
Topological domain | 350-352 | Cytoplasmic | ||||
Sequence: GRR | ||||||
Transmembrane | 353-373 | Helical; Name=9 | ||||
Sequence: RILFIGAAGGSLCMWFIGAYI | ||||||
Topological domain | 374-389 | Extracellular | ||||
Sequence: KIADPGSNKAEDAKLT | ||||||
Transmembrane | 390-410 | Helical; Name=10 | ||||
Sequence: SGGIAAIFFFYLWTAFYTPSW | ||||||
Topological domain | 411-435 | Cytoplasmic | ||||
Sequence: NGTPWVINSEMFDQNTRSLGQASAA | ||||||
Transmembrane | 436-456 | Helical; Name=11 | ||||
Sequence: ANNWFWNFIISRFTPQMFIKM | ||||||
Topological domain | 457-458 | Extracellular | ||||
Sequence: EY | ||||||
Transmembrane | 459-479 | Helical; Name=12 | ||||
Sequence: GVYFFFASLMLLSIVFIYFFL | ||||||
Topological domain | 480-537 | Cytoplasmic | ||||
Sequence: PETKSIPLEAMDRLFEIKPVQNANKNLMAELNFDRNPEREESSSLDDKDRVTQTENAV |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Impairs growth on quinic acid as a sole carbon source and leads to very low inducible levels of qa-2 and qa-3 enzyme activities.
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000050449 | 1-537 | MFS-type transporter qa-x | |||
Sequence: MTLLALKEDRPTPKAVYNWRVYTCAAIASFASCMIGYDSAFIGTTLALPSFTKEFDFASYTPGALALLQSNIVSVYQAGAFFGCLFAYATSYFLGRRKSLIAFSVVFIIGAAIMLAADGQGRGIDPIIAGRVLAGIGVGGASNMVPIYISELAPPAVRGRLVGIYELGWQIGGLVGFWINYGVNTTMAPTRSQWLIPFAVQLIPAGLLFLGSFWIPESPRWLYANGKREEAMKVLCWIRNLEPTDRYIVQEVSFIDADLERYTRQVGNGFWKPFLSLKQRKVQWRFFLGGMLFFWQNGSGINAINYYSPTVFRSIGITGTDTGFLTTGIFGVVKMVLTIIWLLWLVDLVGRRRILFIGAAGGSLCMWFIGAYIKIADPGSNKAEDAKLTSGGIAAIFFFYLWTAFYTPSWNGTPWVINSEMFDQNTRSLGQASAAANNWFWNFIISRFTPQMFIKMEYGVYFFFASLMLLSIVFIYFFLPETKSIPLEAMDRLFEIKPVQNANKNLMAELNFDRNPEREESSSLDDKDRVTQTENAV | ||||||
Glycosylation | 184 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Induction
Expression is induced in the presence of quinic acid (PubMed:6458044).
The quinic acid (qa) gene cluster is subject to two levels of gene control: a primary system which responds to the presence of quinic acid via the qa-1S repressor protein that blocks the qa-1F activator, and a secondary system which represses transcription of qa genes in the presence of a preferred carbon source such as glucose (PubMed:12477937, PubMed:17597928, PubMed:19236936, PubMed:6458044).
The quinic acid (qa) gene cluster is subject to two levels of gene control: a primary system which responds to the presence of quinic acid via the qa-1S repressor protein that blocks the qa-1F activator, and a secondary system which represses transcription of qa genes in the presence of a preferred carbon source such as glucose (PubMed:12477937, PubMed:17597928, PubMed:19236936, PubMed:6458044).
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 514-537 | Disordered | ||||
Sequence: RNPEREESSSLDDKDRVTQTENAV |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length537
- Mass (Da)60,134
- Last updated2004-04-13 v2
- Checksum89D53413EFC164F3
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 481 | in Ref. 1; CAA32752 | ||||
Sequence: E → V |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X14603 EMBL· GenBank· DDBJ | CAA32752.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CM002242 EMBL· GenBank· DDBJ | EAA30380.1 EMBL· GenBank· DDBJ | Genomic DNA |