P11636 · QAY_NEUCR

Function

function

MFS-type transporter; part of the qa gene cluster that mediates the catabolism of quinic acid (QA) and as such, allows the use of QA as a sole carbon source (PubMed:2525625, PubMed:6458044).
Involved in the upatke of QA (PubMed:1533844).
The qa cluster encodes 3 inducible enymes (qa-2, qa-3 and qa-4) catalyzing the first three reactions in the catabolism of quinic acid to protocatechuic acid (also known as 3,4-Dihydroxybenzoic acid) (Probable)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Molecular Functioncarbohydrate:proton symporter activity
Biological Processcarbohydrate transport
Biological Processquinate metabolic process

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    MFS-type transporter qa-x
  • Alternative names
    • Quinate permease
    • Quinate transporter
    • Quinic acid degradation cluster protein y

Gene names

    • Name
      qa-y
    • ORF names
      NCU06026

Organism names

Accessions

  • Primary accession
    P11636
  • Secondary accessions
    • Q7RVA0

Proteomes

    • Identifier
    • Component
      Chromosome 7, Linkage Group VII

Organism-specific databases

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-26Cytoplasmic
Transmembrane27-47Helical; Name=1
Topological domain48-74Extracellular
Transmembrane75-95Helical; Name=2
Topological domain96-98Cytoplasmic
Transmembrane99-119Helical; Name=3
Topological domain120-131Extracellular
Transmembrane132-152Helical; Name=4
Topological domain153-160Cytoplasmic
Transmembrane161-181Helical; Name=5
Topological domain182-195Extracellular
Transmembrane196-216Helical; Name=6
Topological domain217-285Cytoplasmic
Transmembrane286-306Helical; Name=7
Topological domain307-327Extracellular
Transmembrane328-349Helical; Name=8
Topological domain350-352Cytoplasmic
Transmembrane353-373Helical; Name=9
Topological domain374-389Extracellular
Transmembrane390-410Helical; Name=10
Topological domain411-435Cytoplasmic
Transmembrane436-456Helical; Name=11
Topological domain457-458Extracellular
Transmembrane459-479Helical; Name=12
Topological domain480-537Cytoplasmic

Keywords

Phenotypes & Variants

Disruption phenotype

Impairs growth on quinic acid as a sole carbon source and leads to very low inducible levels of qa-2 and qa-3 enzyme activities.

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00000504491-537MFS-type transporter qa-x
Glycosylation184N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Induction

Expression is induced in the presence of quinic acid (PubMed:6458044).
The quinic acid (qa) gene cluster is subject to two levels of gene control: a primary system which responds to the presence of quinic acid via the qa-1S repressor protein that blocks the qa-1F activator, and a secondary system which represses transcription of qa genes in the presence of a preferred carbon source such as glucose (PubMed:12477937, PubMed:17597928, PubMed:19236936, PubMed:6458044).

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region514-537Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    537
  • Mass (Da)
    60,134
  • Last updated
    2004-04-13 v2
  • Checksum
    89D53413EFC164F3
MTLLALKEDRPTPKAVYNWRVYTCAAIASFASCMIGYDSAFIGTTLALPSFTKEFDFASYTPGALALLQSNIVSVYQAGAFFGCLFAYATSYFLGRRKSLIAFSVVFIIGAAIMLAADGQGRGIDPIIAGRVLAGIGVGGASNMVPIYISELAPPAVRGRLVGIYELGWQIGGLVGFWINYGVNTTMAPTRSQWLIPFAVQLIPAGLLFLGSFWIPESPRWLYANGKREEAMKVLCWIRNLEPTDRYIVQEVSFIDADLERYTRQVGNGFWKPFLSLKQRKVQWRFFLGGMLFFWQNGSGINAINYYSPTVFRSIGITGTDTGFLTTGIFGVVKMVLTIIWLLWLVDLVGRRRILFIGAAGGSLCMWFIGAYIKIADPGSNKAEDAKLTSGGIAAIFFFYLWTAFYTPSWNGTPWVINSEMFDQNTRSLGQASAAANNWFWNFIISRFTPQMFIKMEYGVYFFFASLMLLSIVFIYFFLPETKSIPLEAMDRLFEIKPVQNANKNLMAELNFDRNPEREESSSLDDKDRVTQTENAV

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict481in Ref. 1; CAA32752

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X14603
EMBL· GenBank· DDBJ
CAA32752.1
EMBL· GenBank· DDBJ
Genomic DNA
CM002242
EMBL· GenBank· DDBJ
EAA30380.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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