P11633 · NHP6B_YEAST

Function

function

DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex. Required for transcriptional initiation fidelity of some but not all tRNA genes. Seems to be functionally redundant with NHP6A.

Miscellaneous

Present with 4590 molecules/cell in log phase SD medium.

Features

Showing features for dna binding.

199102030405060708090
TypeIDPosition(s)Description
DNA binding27-95HMG box

GO annotations

AspectTerm
Cellular Componentchromosome
Cellular Componentnucleus
Molecular FunctionDNA binding, bending
Molecular Functionsequence-specific DNA binding
Biological Processchromatin remodeling
Biological ProcessDNA repair
Biological Processmaintenance of transcriptional fidelity during transcription elongation by RNA polymerase III
Biological ProcessRNA polymerase III preinitiation complex assembly
Biological Processtranscription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Non-histone chromosomal protein 6B

Gene names

    • Name
      NHP6B
    • Synonyms
      NHPB
    • ORF names
      YBR090BC
    • Ordered locus names
      YBR089C-A

Organism names

Accessions

  • Primary accession
    P11633
  • Secondary accessions
    • A2TBM2
    • D6VQ90
    • P89500
    • P89501

Proteomes

Organism-specific databases

Subcellular Location

Nucleus
Chromosome

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000485661-99Non-histone chromosomal protein 6B

Proteomic databases

PTM databases

Interaction

Subunit

Weakly associates with the stable SPT16-POB3 heterodimer to form the FACT (yFACT or SNP) complex, which is associated with nucleosomes. Multiple molecules of NHP6 (NHP6A and/or NHP6B) are required to recruit the SPT16-POB3 heterodimer to DNA.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-31Disordered
Region69-99Disordered

Sequence similarities

Belongs to the NHP6 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    99
  • Mass (Da)
    11,476
  • Last updated
    2011-07-27 v3
  • Checksum
    0243FDC7D19B8A59
MAATKEAKQPKEPKKRTTRRKKDPNAPKRGLSAYMFFANENRDIVRSENPDVTFGQVGRILGERWKALTAEEKQPYESKAQADKKRYESEKELYNATRA

Sequence caution

The sequence X78993 differs from that shown. Reason: Frameshift

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict30in Ref. 2; X78993 and 3; CAA85042

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X15318
EMBL· GenBank· DDBJ
CAA33378.1
EMBL· GenBank· DDBJ
Genomic DNA
X78993
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
Z35957
EMBL· GenBank· DDBJ
CAA85040.1
EMBL· GenBank· DDBJ
Genomic DNA
Z35959
EMBL· GenBank· DDBJ
CAA85042.1
EMBL· GenBank· DDBJ
Genomic DNA
AY558566
EMBL· GenBank· DDBJ
AAS56892.1
EMBL· GenBank· DDBJ
Genomic DNA
EF123125
EMBL· GenBank· DDBJ
ABM97469.1
EMBL· GenBank· DDBJ
mRNA
BK006936
EMBL· GenBank· DDBJ
DAA07210.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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