P10858 · YADA_YERPS
- ProteinAdhesin YadA
- GeneyadA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids432 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Collagen-binding outer membrane protein forming a fibrillar matrix on the bacterial cell surface. Promotes attachment to eukaryotic cells and after invasion, is the major adhesin in infected tissue. Constitutes an alternative uptake pathway under conditions in which invasin synthesis is repressed.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell outer membrane | |
Cellular Component | cell surface | |
Molecular Function | collagen binding | |
Biological Process | cell adhesion | |
Biological Process | protein transport |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameAdhesin YadA
- Alternative names
Gene names
Encoded on
- Plasmid pIB1
- Plasmid pYV
Organism names
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Yersiniaceae > Yersinia
Accessions
- Primary accessionP10858
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Note: The C-terminal translocator domain is localized in the outer membrane and the passenger domain is at the cell surface.
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 379-389 | Beta stranded | ||||
Sequence: GKVNFTAGVGG | ||||||
Transmembrane | 393-404 | Beta stranded | ||||
Sequence: SQALAIGSGYRV | ||||||
Transmembrane | 411-417 | Beta stranded | ||||
Sequence: KAGVAYA | ||||||
Transmembrane | 421-432 | Beta stranded | ||||
Sequence: NVMYNASFNIEW |
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 95-104 | in strain: YPIII | ||||
Sequence: GLDARAKGIH → AGGLNARAKDPY | ||||||
Natural variant | 124 | in strain: YPIII | ||||
Sequence: A → S | ||||||
Natural variant | 209 | in strain: YPIII | ||||
Sequence: L → H | ||||||
Natural variant | 237-239 | in strain: YPIII | ||||
Sequence: KDN → EDT |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 4 variants from UniProt as well as other sources including ClinVar and dbSNP.
Miscellaneous
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-25 | |||||
Sequence: MTKDFKISVSAALISALFSSPYAFA | ||||||
Chain | PRO_0000022701 | 26-432 | Adhesin YadA | |||
Sequence: EEPEDGNDGIPRLSAVQISPNVDPKLGVGLYPAKPILRQENPKLPPRGPQGPEKKRARLAEAIQPQVLGGLDARAKGIHSIAIGATAEAAKPAAVAVGAGSIATGVNSVAIGPLSKALGDSAVTYGASSTAQKDGVAIGARASASDTGVAVGFNSKVDAQNSVAIGHSSHVAADHGYSIAIGDLSKTDRENSVSIGHESLNRQLTHLAAGTKDNDAVNVAQLKKEMAETLENARKETLAQSNDVLDAAKKHSNSVARTTLETAEEHANKKSAEALVSAKVYADSNSSHTLKTANSYTDVTVSSSTKKAISESNQYTDHKFSQLDNRLDKLDKRVDKGLASSAALNSLFQPYGVGKVNFTAGVGGYRSSQALAIGSGYRVNESVALKAGVAYAGSSNVMYNASFNIEW |
Expression
Induction
Induced at 37 degrees Celsius by the temperature-dependent transcriptional activator LcrF (VirF).
Interaction
Subunit
Homotrimer.
Structure
Family & Domains
Features
Showing features for region, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 26-340 | Surface exposed passenger domain | ||||
Sequence: EEPEDGNDGIPRLSAVQISPNVDPKLGVGLYPAKPILRQENPKLPPRGPQGPEKKRARLAEAIQPQVLGGLDARAKGIHSIAIGATAEAAKPAAVAVGAGSIATGVNSVAIGPLSKALGDSAVTYGASSTAQKDGVAIGARASASDTGVAVGFNSKVDAQNSVAIGHSSHVAADHGYSIAIGDLSKTDRENSVSIGHESLNRQLTHLAAGTKDNDAVNVAQLKKEMAETLENARKETLAQSNDVLDAAKKHSNSVARTTLETAEEHANKKSAEALVSAKVYADSNSSHTLKTANSYTDVTVSSSTKKAISESNQY | ||||||
Coiled coil | 242-263 | |||||
Sequence: VNVAQLKKEMAETLENARKETL | ||||||
Region | 341-379 | Outer membrane translocation of the passenger domain | ||||
Sequence: TDHKFSQLDNRLDKLDKRVDKGLASSAALNSLFQPYGVG | ||||||
Region | 380-432 | Translocator domain | ||||
Sequence: KVNFTAGVGGYRSSQALAIGSGYRVNESVALKAGVAYAGSSNVMYNASFNIEW |
Domain
The signal peptide, cleaved at the inner membrane, guides the autotransporter protein to the periplasmic space. Then, insertion of the C-terminal translocator domain in the outer membrane forms a hydrophilic pore for the translocation of the passenger domain to the bacterial cell surface.
Sequence similarities
Belongs to the autotransporter-2 (AT-2) (TC 1.B.40) family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length432
- Mass (Da)44,831
- Last updated2004-11-23 v2
- Checksum4698FF92AB0D035B
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X13883 EMBL· GenBank· DDBJ | CAA32088.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX936399 EMBL· GenBank· DDBJ | CAF25356.1 EMBL· GenBank· DDBJ | Genomic DNA |