P10589 · COT1_HUMAN
- ProteinCOUP transcription factor 1
- GeneNR2F1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids423 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG.
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 83-158 | Nuclear receptor | ||||
Sequence: HIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQR |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleoplasm | |
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription factor activity | |
Molecular Function | DNA-binding transcription repressor activity, RNA polymerase II-specific | |
Molecular Function | nuclear receptor activity | |
Molecular Function | retinoic acid-responsive element binding | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Molecular Function | sequence-specific DNA binding | |
Molecular Function | sequence-specific double-stranded DNA binding | |
Molecular Function | zinc ion binding | |
Biological Process | cell differentiation | |
Biological Process | negative regulation of neuron projection development | |
Biological Process | negative regulation of transcription by RNA polymerase II | |
Biological Process | nervous system development | |
Biological Process | positive regulation of transcription by RNA polymerase II | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCOUP transcription factor 1
- Short namesCOUP-TF1
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP10589
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Involvement in disease
Bosch-Boonstra-Schaaf optic atrophy syndrome (BBSOAS)
- Note
- DescriptionAn autosomal dominant disorder characterized by optic atrophy associated with developmental delay and intellectual disability. Most patients also have evidence of cerebral visual impairment.
- See alsoMIM:615722
Natural variants in BBSOAS
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_071319 | 112 | R>K | in BBSOAS; decreases transcriptional activity; dbSNP:rs587777277 | |
VAR_071320 | 113 | S>R | in BBSOAS; decreases transcriptional activity; dbSNP:rs587777275 | |
VAR_071321 | 115 | R>P | in BBSOAS; decreases transcriptional activity; dbSNP:rs587777274 | |
VAR_071322 | 252 | L>P | in BBSOAS; decreases transcriptional activity; dbSNP:rs587777276 |
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_078708 | 110 | found in a patient with early infantile epileptic encephalopathy; likely pathogenic | |||
Sequence: Missing | ||||||
Natural variant | VAR_071319 | 112 | in BBSOAS; decreases transcriptional activity; dbSNP:rs587777277 | |||
Sequence: R → K | ||||||
Natural variant | VAR_071320 | 113 | in BBSOAS; decreases transcriptional activity; dbSNP:rs587777275 | |||
Sequence: S → R | ||||||
Natural variant | VAR_071321 | 115 | in BBSOAS; decreases transcriptional activity; dbSNP:rs587777274 | |||
Sequence: R → P | ||||||
Natural variant | VAR_071322 | 252 | in BBSOAS; decreases transcriptional activity; dbSNP:rs587777276 | |||
Sequence: L → P |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 467 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000053602 | 1-423 | UniProt | COUP transcription factor 1 | |||
Sequence: MAMVVSSWRDPQDDVAGGNPGGPNPAAQAARGGGGGAGEQQQQAGSGAPHTPQTPGQPGAPATPGTAGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMSIQCS | |||||||
Modified residue (large scale data) | 51 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 54 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 63 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 77 | PRIDE | Phosphoserine | ||||
Sequence: S |
Proteomic databases
PTM databases
Expression
Induction
Inhibited by gonadotropin in granulosa cells.
Gene expression databases
Organism-specific databases
Interaction
Structure
Family & Domains
Features
Showing features for region, compositional bias, zinc finger, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-81 | Disordered | ||||
Sequence: MAMVVSSWRDPQDDVAGGNPGGPNPAAQAARGGGGGAGEQQQQAGSGAPHTPQTPGQPGAPATPGTAGDKGQGPPGSGQSQ | ||||||
Compositional bias | 39-53 | Polar residues | ||||
Sequence: EQQQQAGSGAPHTPQ | ||||||
Zinc finger | 86-106 | NR C4-type | ||||
Sequence: CVVCGDKSSGKHYGQFTCEGC | ||||||
Zinc finger | 122-146 | NR C4-type | ||||
Sequence: CRANRNCPIDQHHRNQCQYCRLKKC | ||||||
Domain | 184-410 | NR LBD | ||||
Sequence: YLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSG |
Sequence similarities
Belongs to the nuclear hormone receptor family. NR2 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length423
- Mass (Da)46,156
- Last updated1989-07-01 v1
- Checksum6EE634BE96242731
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8V8TQQ6 | A0A8V8TQQ6_HUMAN | NR2F1 | 273 | ||
A0A8V8TPV3 | A0A8V8TPV3_HUMAN | NR2F1 | 263 | ||
F1DAL7 | F1DAL7_HUMAN | NR2F1 | 372 | ||
F1DAL9 | F1DAL9_HUMAN | NR2F1 | 398 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 39-53 | Polar residues | ||||
Sequence: EQQQQAGSGAPHTPQ |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X16155 EMBL· GenBank· DDBJ | CAA34277.1 EMBL· GenBank· DDBJ | mRNA | ||
X12795 EMBL· GenBank· DDBJ | CAA31283.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC004154 EMBL· GenBank· DDBJ | AAH04154.1 EMBL· GenBank· DDBJ | mRNA | ||
BC017493 EMBL· GenBank· DDBJ | AAH17493.1 EMBL· GenBank· DDBJ | mRNA |