P10174 · COX7_YEAST
- ProteinCytochrome c oxidase subunit 7, mitochondrial
- GeneCOX7
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Miscellaneous
Present with 639 molecules/cell in log phase SD medium.
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial membrane | |
Cellular Component | mitochondrial respiratory chain complex IV | |
Cellular Component | mitochondrion | |
Molecular Function | oxidoreductase activity | |
Biological Process | cellular respiration | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen | |
Biological Process | proton transmembrane transport |
Keywords
- Molecular function
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 7, mitochondrial
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP10174
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Single-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 2-29 | Mitochondrial matrix | ||||
Sequence: ANKVIQLQKIFQSSTKPLWWRHPRSALY | ||||||
Transmembrane | 30-53 | Helical | ||||
Sequence: LYPFYAIFAVAVVTPLLYIPNAIR | ||||||
Topological domain | 54-60 | Mitochondrial intermembrane | ||||
Sequence: GIKAKKA |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for initiator methionine, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Chain | PRO_0000183907 | 2-60 | Cytochrome c oxidase subunit 7, mitochondrial | |||
Sequence: ANKVIQLQKIFQSSTKPLWWRHPRSALYLYPFYAIFAVAVVTPLLYIPNAIRGIKAKKA |
Proteomic databases
Interaction
Subunit
Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 12 subunits. The complex is composed of a catalytic core of 3 subunits COX1, COX2 and COX3, encoded in the mitochondrial DNA, and 9 supernumerary subunits COX4, COX5A (or COX5B), COX6, COX7, COX8, COX9, COX12, COX13 and COX26, which are encoded in the nuclear genome (PubMed:30598554, PubMed:30598556, PubMed:7851399).
The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a dimer of ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in 2 different assemblies (supercomplexes III2IV and III2IV2) (PubMed:10764779, PubMed:10775262, PubMed:30598554, PubMed:30598556).
The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a dimer of ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in 2 different assemblies (supercomplexes III2IV and III2IV2) (PubMed:10764779, PubMed:10775262, PubMed:30598554, PubMed:30598556).
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Sequence similarities
Belongs to the cytochrome c oxidase VIIa family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length60
- Mass (Da)6,932
- Last updated2007-01-23 v3
- Checksum5798C96AF8134D6D
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X51506 EMBL· GenBank· DDBJ | CAA35871.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M31620 EMBL· GenBank· DDBJ | AAA34550.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z48639 EMBL· GenBank· DDBJ | CAA88583.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY558129 EMBL· GenBank· DDBJ | AAS56455.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006946 EMBL· GenBank· DDBJ | DAA10156.1 EMBL· GenBank· DDBJ | Genomic DNA |