P10174 · COX7_YEAST

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Miscellaneous

Present with 639 molecules/cell in log phase SD medium.

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial membrane
Cellular Componentmitochondrial respiratory chain complex IV
Cellular Componentmitochondrion
Molecular Functionoxidoreductase activity
Biological Processcellular respiration
Biological Processmitochondrial electron transport, cytochrome c to oxygen
Biological Processproton transmembrane transport

Keywords

Enzyme and pathway databases

Protein family/group databases

    • 3.D.4.8.1the proton-translocating cytochrome oxidase (cox) superfamily

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 7, mitochondrial
  • Alternative names
    • Cytochrome c oxidase polypeptide VII

Gene names

    • Name
      COX7
    • ORF names
      YM9920.10C
    • Ordered locus names
      YMR256C

Organism names

Accessions

  • Primary accession
    P10174
  • Secondary accessions
    • D6W082

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain2-29Mitochondrial matrix
Transmembrane30-53Helical
Topological domain54-60Mitochondrial intermembrane

Keywords

PTM/Processing

Features

Showing features for initiator methionine, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
ChainPRO_00001839072-60Cytochrome c oxidase subunit 7, mitochondrial

Proteomic databases

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 12 subunits. The complex is composed of a catalytic core of 3 subunits COX1, COX2 and COX3, encoded in the mitochondrial DNA, and 9 supernumerary subunits COX4, COX5A (or COX5B), COX6, COX7, COX8, COX9, COX12, COX13 and COX26, which are encoded in the nuclear genome (PubMed:30598554, PubMed:30598556, PubMed:7851399).
The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a dimer of ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in 2 different assemblies (supercomplexes III2IV and III2IV2) (PubMed:10764779, PubMed:10775262, PubMed:30598554, PubMed:30598556).
View interactors in UniProtKB
View CPX-1721 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Sequence

  • Sequence status
    Complete
  • Length
    60
  • Mass (Da)
    6,932
  • Last updated
    2007-01-23 v3
  • Checksum
    5798C96AF8134D6D
MANKVIQLQKIFQSSTKPLWWRHPRSALYLYPFYAIFAVAVVTPLLYIPNAIRGIKAKKA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X51506
EMBL· GenBank· DDBJ
CAA35871.1
EMBL· GenBank· DDBJ
Genomic DNA
M31620
EMBL· GenBank· DDBJ
AAA34550.1
EMBL· GenBank· DDBJ
Genomic DNA
Z48639
EMBL· GenBank· DDBJ
CAA88583.1
EMBL· GenBank· DDBJ
Genomic DNA
AY558129
EMBL· GenBank· DDBJ
AAS56455.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006946
EMBL· GenBank· DDBJ
DAA10156.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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