P10155 · RO60_HUMAN

  • Protein
    RNA-binding protein RO60
  • Gene
    RO60
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs (PubMed:18056422, PubMed:26382853).
Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammatory cytokine secretion (PubMed:26382853).
Regulates the expression of Alu retroelements as well as inflammatory genes (PubMed:26382853).
May play roles in cilia formation and/or maintenance (By similarity).

Miscellaneous

Antibodies against normal cellular SSA2 protein are found in sera from patients with systemic lupus erythematosus (SLE).

Features

Showing features for binding site.

153850100150200250300350400450500
TypeIDPosition(s)Description
Binding site378a divalent metal cation (UniProtKB | ChEBI)
Binding site380a divalent metal cation (UniProtKB | ChEBI)
Binding site445a divalent metal cation (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentnuclear body
Cellular Componentnucleoplasm
Cellular Componentribonucleoprotein complex
Molecular Functionmetal ion binding
Molecular FunctionRNA binding
Molecular FunctionU2 snRNA binding
Biological Processcellular response to interferon-alpha
Biological Processcilium assembly
Biological Processimmune system development
Biological Processregulation of gene expression
Biological Processresponse to UV
Biological Processsmoothened signaling pathway
Biological Processtranscription by RNA polymerase III

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    RNA-binding protein RO60
  • Alternative names
    • 60 kDa SS-A/Ro ribonucleoprotein
      (60 kDa Ro protein; 60 kDa ribonucleoprotein Ro; RoRNP)
    • Ro 60 kDa autoantigen
      (Ro60 autoantigen
      )
    • Sjoegren syndrome antigen A2
    • Sjoegren syndrome type A antigen
      (SS-A
      )
    • TROVE domain family member 2

Gene names

    • Name
      RO60
    • Synonyms
      SSA2
      , TROVE2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P10155
  • Secondary accessions
    • B2RBB9
    • Q5LJ98
    • Q5LJ99
    • Q5LJA0
    • Q86WL3

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 589 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue, chain, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue1UniProtN-acetylmethionine
ChainPRO_00001741691-538UniProtRNA-binding protein RO60
Modified residue4UniProtPhosphoserine
Modified residue19UniProtPhosphoserine
Modified residue (large scale data)19PRIDEPhosphoserine
Modified residue (large scale data)23PRIDEPhosphotyrosine
Modified residue224UniProtN6-acetyllysine
Modified residue359UniProtN6-acetyllysine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661).
Found in a complex with PUF60 and Y5 RNA (PubMed:10668799).
Interacts with RAB11FIP5 (PubMed:10545525).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain16-369TROVE
Region120-284RNA-binding
Region361-538VWFA-like domain

Domain

The horseshoe-shaped TROVE domain is built with 7 helical HEAT-like repeats, and is closed by the VWFA-like domain giving rise to a ring-shaped monomer. Single-stranded RNA is bound in the positively charged central cavity (By similarity).
The MIDAS-like motif in the VWFA-like domain binds divalent metal cations.

Sequence similarities

Belongs to the Ro 60 kDa family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (5)
  • Sequence status
    Complete

This entry describes 5 isoforms produced by Alternative splicing.

P10155-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    Long
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    538
  • Mass (Da)
    60,671
  • Last updated
    2004-09-27 v2
  • Checksum
    CD735B1DF2B13098
MEESVNQMQPLNEKQIANSQDGYVWQVTDMNRLHRFLCFGSEGGTYYIKEQKLGLENAEALIRLIEDGRGCEVIQEIKSFSQEGRTTKQEPMLFALAICSQCSDISTKQAAFKAVSEVCRIPTHLFTFIQFKKDLKESMKCGMWGRALRKAIADWYNEKGGMALALAVTKYKQRNGWSHKDLLRLSHLKPSSEGLAIVTKYITKGWKEVHELYKEKALSVETEKLLKYLEAVEKVKRTRDELEVIHLIEEHRLVREHLLTNHLKSKEVWKALLQEMPLTALLRNLGKMTANSVLEPGNSEVSLVCEKLCNEKLLKKARIHPFHILIALETYKTGHGLRGKLKWRPDEEILKALDAAFYKTFKTVEPTGKRFLLAVDVSASMNQRVLGSILNASTVAAAMCMVVTRTEKDSYVVAFSDEMVPCPVTTDMTLQQVLMAMSQIPAGGTDCSLPMIWAQKTNTPADVFIVFTDNETFAGGVHPAIALREYRKKMDIPAKLIVCGMTSNGFTIADPDDRGMLDMCGFDTGALDVIRNFTLDMI

P10155-2

  • Name
    Short
  • Synonyms
    60E2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

P10155-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 515-538: GMLDMCGFDTGALDVIRNFTLDMI → DTVK

P10155-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

P10155-5

  • Name
    5
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 515-538: GMLDMCGFDTGALDVIRNFTLDMI → ALQNTLLNKSF

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
D6RE09D6RE09_HUMANRO6066
D6RDN1D6RDN1_HUMANRO6041
H0Y9N5H0Y9N5_HUMANRO60193
G5E9R9G5E9R9_HUMANRO60263

Features

Showing features for sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Sequence conflict136in Ref. 4; AAO47001/AAO47002
Alternative sequenceVSP_005911195-205in isoform Short
Alternative sequenceVSP_005912206-538in isoform Short
Sequence conflict239in Ref. 1; AAA35493
Alternative sequenceVSP_045262515-538in isoform 3
Alternative sequenceVSP_054041515-538in isoform 5
Alternative sequenceVSP_045797529-538in isoform 4

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
J04137
EMBL· GenBank· DDBJ
AAA35493.1
EMBL· GenBank· DDBJ
mRNA
M25077
EMBL· GenBank· DDBJ
AAA35532.1
EMBL· GenBank· DDBJ
mRNA
U44388
EMBL· GenBank· DDBJ
AAB81552.1
EMBL· GenBank· DDBJ
Genomic DNA Different termination.
U44388
EMBL· GenBank· DDBJ
AAB81553.1
EMBL· GenBank· DDBJ
Genomic DNA
AY205314
EMBL· GenBank· DDBJ
AAO47001.1
EMBL· GenBank· DDBJ
mRNA
AY205315
EMBL· GenBank· DDBJ
AAO47002.1
EMBL· GenBank· DDBJ
mRNA
AK314594
EMBL· GenBank· DDBJ
BAG37166.1
EMBL· GenBank· DDBJ
mRNA
AL136370
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471067
EMBL· GenBank· DDBJ
EAW91240.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471067
EMBL· GenBank· DDBJ
EAW91243.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471067
EMBL· GenBank· DDBJ
EAW91245.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471067
EMBL· GenBank· DDBJ
EAW91247.1
EMBL· GenBank· DDBJ
Genomic DNA
BC036658
EMBL· GenBank· DDBJ
AAH36658.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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