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P10072 · ZN875_HUMAN

  • Protein
    Zinc finger protein 875
  • Gene
    ZNF875
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

May be involved in transcriptional regulation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Functionzinc ion binding
Biological Processregulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Community curation (1)

Community annotation

The subsequence MSCSGAGGITAFVAFRDVAVYFTQEEWRLLSPAQRTLHREVMLETYNHLVSLEIPSSKPKLIAQLERGEAPWREERKCPL shows transcriptional repressor activity in a high-throughput recruitment assay.

SourceSubmission dateContributor
PubMed:333267460000-0002-4108-0575

Names & Taxonomy

Protein names

  • Recommended name
    Zinc finger protein 875
  • Alternative names
    • Krueppel-related zinc finger protein 1
    • Protein HKR1

Gene names

    • Name
      ZNF875
    • Synonyms
      HKR1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P10072
  • Secondary accessions
    • A8MRS7
    • Q6PJD0
    • Q9BSW9
    • Q9UM09

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_047404448in dbSNP:rs2921563
Natural variantVAR_047405513in dbSNP:rs3745765
Natural variantVAR_047406628in dbSNP:rs3745764

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 122 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data).

Type
IDPosition(s)Source
Description
ChainPRO_00000472701-659UniProtZinc finger protein 875
Modified residue (large scale data)219PRIDEPhosphoserine
Modified residue (large scale data)220PRIDEPhosphoserine

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, compositional bias, region, zinc finger.

Type
IDPosition(s)Description
Domain33-104KRAB
Compositional bias191-215Polar residues
Region191-229Disordered
Zinc finger301-323C2H2-type 1
Zinc finger329-351C2H2-type 2
Zinc finger357-379C2H2-type 3
Zinc finger385-407C2H2-type 4
Zinc finger413-435C2H2-type 5
Zinc finger441-463C2H2-type 6
Zinc finger469-491C2H2-type 7
Zinc finger497-519C2H2-type 8
Zinc finger525-547C2H2-type 9
Zinc finger553-575C2H2-type 10
Zinc finger579-601C2H2-type 11
Zinc finger607-629C2H2-type 12
Zinc finger635-657C2H2-type 13

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

P10072-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    659
  • Mass (Da)
    75,128
  • Last updated
    2008-11-25 v4
  • MD5 Checksum
    5596759DE0D2E6E6A726272C3B42B8D9
MRVNHTVSTMLPTCMVHRQTMSCSGAGGITAFVAFRDVAVYFTQEEWRLLSPAQRTLHREVMLETYNHLVSLEIPSSKPKLIAQLERGEAPWREERKCPLDLCPESKPEIQLSPSCPLIFSSQQALSQHVWLSHLSQLFSSLWAGNPLHLGKHYPEDQKQQQDPFCFSGKAEWIQEGEDSRLLFGRVSKNGTSKALSSPPEEQQPAQSKEDNTVVDIGSSPERRADLEETDKVLHGLEVSGFGEIKYEEFGPGFIKESNLLSLQKTQTGETPYMYTEWGDSFGSMSVLIKNPRTHSGGKPYVCRECGRGFTWKSNLITHQRTHSGEKPYVCKDCGRGFTWKSNLFTHQRTHSGLKPYVCKECGQSFSLKSNLITHQRAHTGEKPYVCRECGRGFRQHSHLVRHKRTHSGEKPYICRECEQGFSQKSHLIRHLRTHTGEKPYVCTECGRHFSWKSNLKTHQRTHSGVKPYVCLECGQCFSLKSNLNKHQRSHTGEKPFVCTECGRGFTRKSTLSTHQRTHSGEKPFVCAECGRGFNDKSTLISHQRTHSGEKPFMCRECGRRFRQKPNLFRHKRAHSGAFVCRECGQGFCAKLTLIKHQRAHAGGKPHVCRECGQGFSRQSHLIRHQRTHSGEKPYICRKCGRGFSRKSNLIRHQRTHSG

P10072-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-30: MRVNHTVSTMLPTCMVHRQTMSCSGAGGIT → MATGLLRAKKE

Computationally mapped potential isoform sequences

There are 17 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1B0GXI2A0A1B0GXI2_HUMANZNF87521
A0A494C010A0A494C010_HUMANZNF875117
K7EJS1K7EJS1_HUMANZNF87522
K7EL05K7EL05_HUMANZNF87591
K7EL22K7EL22_HUMANZNF875107
K7EL36K7EL36_HUMANZNF87591
K7EMJ9K7EMJ9_HUMANZNF87541
K7EME6K7EME6_HUMANZNF875171
K7EMG8K7EMG8_HUMANZNF87569
K7EM51K7EM51_HUMANZNF87577
K7ENA5K7ENA5_HUMANZNF87546
K7EPW3K7EPW3_HUMANZNF875641
K7EQG8K7EQG8_HUMANZNF87554
K7ES32K7ES32_HUMANZNF87537
K7ERA5K7ERA5_HUMANZNF875127
F5H6A5F5H6A5_HUMANZNF875386
Q7Z6E1Q7Z6E1_HUMANZNF875598

Sequence caution

The sequence BAA86058.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Features

Showing features for alternative sequence, compositional bias.

Type
IDPosition(s)Description
Alternative sequenceVSP_0357551-30in isoform 2
Compositional bias191-215Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB013897
EMBL· GenBank· DDBJ
BAA86058.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AC016590
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471126
EMBL· GenBank· DDBJ
EAW56722.1
EMBL· GenBank· DDBJ
Genomic DNA
BC004513
EMBL· GenBank· DDBJ
AAH04513.2
EMBL· GenBank· DDBJ
mRNA
BC017256
EMBL· GenBank· DDBJ
AAH17256.1
EMBL· GenBank· DDBJ
mRNA
M20675
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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