P0DXF3 · FAPA_PSEFL
- ProteinFibril amyloid chaperone protein FapA
- GenefapA
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids152 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
An intrinsically disordered chaperone for fibril amyloid FapC that guards against fibrillation within the periplasm (PubMed:36368411).
FapA inhibits FapC fibrillation and elongation of FapB fibrils in vitro (PubMed:36368411).
Upon overexpression of the endogenous six-gene locus (fapA-fapF) in situ, cells form large clumps during liquid growth, make large amounts of biofilm and produce amyloid fibrils (PubMed:23504942, PubMed:26500638).
Expression of the 6 gene operon in E.coli strain BL21(DE3) induces flocculation and biofilm formation with copious extracellular fibrils (PubMed:20572935).
FapA inhibits FapC fibrillation and elongation of FapB fibrils in vitro (PubMed:36368411).
Upon overexpression of the endogenous six-gene locus (fapA-fapF) in situ, cells form large clumps during liquid growth, make large amounts of biofilm and produce amyloid fibrils (PubMed:23504942, PubMed:26500638).
Expression of the 6 gene operon in E.coli strain BL21(DE3) induces flocculation and biofilm formation with copious extracellular fibrils (PubMed:20572935).
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameFibril amyloid chaperone protein FapA
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas
Accessions
- Primary accessionP0DXF3
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-28 | ||||
Chain | PRO_0000461513 | 29-152 | Fibril amyloid chaperone protein FapA | ||
Interaction
Subunit
Monomer in solution. Interacts with FapC but not FapB in vitro (PubMed:36368411).
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length152
- Mass (Da)14,891
- Last updated2024-11-27 v1
- Checksum75CDF55D9EB7CD23
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
ACOQ01000001 EMBL· GenBank· DDBJ | EEP64549.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP008896 EMBL· GenBank· DDBJ | AIG01389.1 EMBL· GenBank· DDBJ | Genomic DNA |