P0DW33 · DPDA_SALMO
- ProteinDNA-guanine transglycosylase
- GenedpdA
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids416 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Part of the dpd cluster involved in the insertion of 7-deazaguanine derivatives in DNA (PubMed:26929322, PubMed:30159947).
DpdA may insert 7-cyano-7-deazaguanine (preQ0) into DNA with the help of DpdB (PubMed:30159947).
DpdA and dpdB are necessary and sufficient to synthesize 2'-deoxy-7-cyano-7-deazaguanosine (dPreQ0) (PubMed:30159947).
DpdA may insert 7-cyano-7-deazaguanine (preQ0) into DNA with the help of DpdB (PubMed:30159947).
DpdA and dpdB are necessary and sufficient to synthesize 2'-deoxy-7-cyano-7-deazaguanosine (dPreQ0) (PubMed:30159947).
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 95 | Proton acceptor | |||
Active site | 256 | Nucleophile | |||
Binding site | 368 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 370 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 373 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 395 | Zn2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | metal ion binding | |
Molecular Function | pentosyltransferase activity | |
Biological Process | tRNA modification |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA-guanine transglycosylase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Salmonella
Accessions
- Primary accessionP0DW33
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000456249 | 1-416 | DNA-guanine transglycosylase | ||
Sequence
- Sequence statusComplete
- Length416
- Mass (Da)48,101
- Last updated2022-08-03 v1
- MD5 ChecksumAE1F1C7EAD68934060D4CA8249ADB92A
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AESH01000017 EMBL· GenBank· DDBJ | EFY12575.1 EMBL· GenBank· DDBJ | Genomic DNA |