P0DUN3 · PA2A1_BOTBZ

Function

function

Snake venom phospholipase A2 (PLA2) that induces significant edematogenic activity. Shows mild cytotoxicity on Trypanosoma cruzi and Leishmania infantum. Also inhibits ADP- and collagen-induced platelet aggregation. Does not show myotoxic activity.

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion.

pH Dependence

Optimum pH is 5.5-8.5.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site27Ca2+ (UniProtKB | ChEBI)
Binding site29Ca2+ (UniProtKB | ChEBI)
Binding site31Ca2+ (UniProtKB | ChEBI)
Active site47
Binding site48Ca2+ (UniProtKB | ChEBI)
Active site80

GO annotations

AspectTerm
Cellular Componentextracellular region
Molecular Functioncalcium ion binding
Molecular Functioncalcium-dependent phospholipase A2 activity
Molecular Functionphospholipid binding
Molecular Functiontoxin activity
Biological Processarachidonic acid secretion
Biological Processlipid catabolic process
Biological Processphospholipid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Acidic phospholipase A2 braziliase-I
  • EC number
  • Short names
    svPLA2
  • Alternative names
    • Phosphatidylcholine 2-acylhydrolase

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Lepidosauria > Squamata > Bifurcata > Unidentata > Episquamata > Toxicofera > Serpentes > Colubroidea > Viperidae > Crotalinae > Bothrops

Accessions

  • Primary accession
    P0DUN3

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00004528941-107Acidic phospholipase A2 braziliase-I
Disulfide bond26↔100
Disulfide bond28↔44
Disulfide bond43↔86
Disulfide bond49↔107
Disulfide bond50↔79
Disulfide bond57↔72
Disulfide bond66↔77

Keywords

Expression

Tissue specificity

Expressed by the venom gland.

Interaction

Subunit

Monomer.

Family & Domains

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Fragments
  • Length
    107
  • Mass (Da)
    12,108
  • Last updated
    2021-06-02 v1
  • Checksum
    3E7FE7ECBD6A14A2
NLWQFEMLIMKIALTSGFMFYSSYGCYCGWGGHGRPKDASDRCCFVHDCCYGKVTTCNPKFGVVVCGGDDPCKKQICECDRVAATCFRDNKYWFYGAKXCQEESDPC

Features

Showing features for non-adjacent residues.

TypeIDPosition(s)Description
Non-adjacent residues61-62
Non-adjacent residues89-90

Mass Spectrometry

Molecular mass is 13,894 Da. Determined by MALDI.

Keywords

Similar Proteins

Disclaimer

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