P0DTN8 · DEPOL_BPKRA
- ProteinDepolymerase, capsule K2-specific
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids907 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Constitutes the tail fiber, which functions as a receptor binding protein (RBP) and mediates the attachment to the host capsular exopolysaccharides (PubMed:34431721).
Displays a depolymerase activity that specifically degrades the K2-type polysaccharides of Klebsiella pneumoniae, which allows the phage to reach the host cell membrane and bind the entry receptor (PubMed:34431721).
Displays a depolymerase activity that specifically degrades the K2-type polysaccharides of Klebsiella pneumoniae, which allows the phage to reach the host cell membrane and bind the entry receptor (PubMed:34431721).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | virus tail, fiber | |
Biological Process | adhesion receptor-mediated virion attachment to host cell | |
Biological Process | symbiont entry into host cell via disruption of host cell envelope | |
Biological Process | symbiont entry into host cell via disruption of host cell glycocalyx |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameDepolymerase, capsule K2-specific
- Short namesDpK2
- Alternative names
Gene names
Organism names
- Taxonomic lineageViruses > Duplodnaviria > Heunggongvirae > Uroviricota > Caudoviricetes > Drexlerviridae > Webervirus
- Virus hosts
Accessions
- Primary accessionP0DTN8
Subcellular Location
UniProt Annotation
GO Annotation
Note: Tail appendage. Forms globular appendages on the phage virion tail tip.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000458739 | 1-907 | Depolymerase, capsule K2-specific | |||
Sequence: MALYREGKAAMAADGTVTGTGTKWQSSLSLIRPGATIMFLSSPIQMAVVNKVVSDTEIKAITTSGAVVASTDYAILLSDSLTVDGLAQDVAETLRHYQSQETVIADAVEFFKSFDFDSLQNLANQIKADSESAESSAAAAAASESKAKTSEDNAKSSENAAKNSEVAAETTRDQIQQIIDNAGDQSTLVVLAQPDGFDSIGRVSSFAALRNLKPKKSGQHVLLTSYYDGWAAENKMPTGGGEFISSIGTATDDGGYIAAGPGYYWTRVVNNNSFTAEDFGCKTTATPPPNFNVLPAELFDNTAMMQAAFNLAISKSFKLNLSTGTYYFESSDTLRITGPIHIEGRPGTVFYHNPSNKANPKTDAFMNISGCSAGRISSINCFSNSYLGKGINFDRSVGDNRKLVLEHVYVDTFRWGFYVGEPECINQIEFHSCRAQSNYFQGIFIESFKEGQEYGHSAPVHFFNTICNGNGPTSFALGATYKTTKNEYIKVMDSVNDVGCQAYFQGLSNVQYIGGQLSGHGSPRNTSLATITQCNSFIIYGTDLEDINGFTTDGTAITADNIDAIESNYLKDISGAAIVVSSCPGFKIDSPHIFKIKTLSTIKLMNNTYNYEIGGFTPDEALKYNVWDANGLATNRISGVIHPRLVNSRLGINSVAFDNMSNKLDVSSLIHNETSQIVGLTPSTGSNVPHTRKMWSNGAMYSSTDLNNGFRLNYLSNHNEPLTPMHLYNEFSVSEFGGSVTESNALDEIKYIFIQTTYANSGDGRFIIQALDASGSVLSSNWYSPQSFNSTFPISGFVRFDVPTGAKKIRYGFVNSANYTGSLRSHFMSGFAYNKRFFLKIYAVYNDLGRYGQFEPPYSVAIDRFRVGDNTTQMPSIPASSATDVAGVNEVINSLLASLKANGFMSS |
Interaction
Subunit
Homotrimer.
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 137-169 | Disordered | ||||
Sequence: AAAAAASESKAKTSEDNAKSSENAAKNSEVAAE |
Domain
The N-terminus contains an extended triple helical bundle (PubMed:34431721).
The central part is a beta-helical domain, which forms a negatively charged cavity at the interface between neighboring monomers (PubMed:34431721).
This cavity may contain the active site (PubMed:34431721).
The C-terminus is formed by 3 four-stranded beta-sandwich folds (PubMed:34431721).
The central part is a beta-helical domain, which forms a negatively charged cavity at the interface between neighboring monomers (PubMed:34431721).
This cavity may contain the active site (PubMed:34431721).
The C-terminus is formed by 3 four-stranded beta-sandwich folds (PubMed:34431721).
Sequence similarities
In the N-terminal section; belongs to the Webervirus depolymerase family.
In the C-terminal section; belongs to the K2-specific depolymerase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length907
- Mass (Da)98,355
- Last updated2023-09-13 v1
- Checksum50D98EB43856BF21
Keywords
- Technical term