P0DTL6 · ZTRF1_HUMAN

  • Protein
    Zinc finger TRAF-type-containing protein 1
  • Gene
    ZFTRAF1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentperinuclear region of cytoplasm
Molecular Functionzinc ion binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Zinc finger TRAF-type-containing protein 1
  • Alternative names
    • Cysteine and histidine-rich protein 1

Gene names

    • Name
      ZFTRAF1
    • Synonyms
      CYHR1, KIAA0496

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P0DTL6
  • Secondary accessions
    • B3KSX0
    • D3DWM3
    • E9PJD7
    • Q6ZMK1
    • Q9BSF6
    • Q9BSU6

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Note: Shows a prominent perinuclear and cytoplasmic localization.

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 292 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003288521-404Zinc finger TRAF-type-containing protein 1

Proteomic databases

PTM databases

Expression

Gene expression databases

    • ENSG00000187954Expressed in right hemisphere of cerebellum and 179 other cell types or tissues

Interaction

Subunit

Interacts with LGALS3.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P0DTL6UBE2K P610863EBI-10984242, EBI-473850

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, zinc finger.

TypeIDPosition(s)Description
Region1-22Disordered
Zinc finger111-156RING-type; degenerate
Zinc finger152-225TRAF-type

Sequence similarities

Belongs to the ZFTRAF1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (4)
  • Sequence status
    Complete

This entry describes 4 isoforms produced by Alternative splicing.

P0DTL6-5

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    404
  • Mass (Da)
    43,813
  • Last updated
    2022-10-12 v1
  • Checksum
    0A272CC6662AF5F9
MSGAEEAGGGGPAAGPAGSVPAGVGVGVGAGPGAAAGQAAAAALGEAAGPGLPDEAGLAGARQLQLQEAAGDPDAPPKKRLRAAEAAEAAAAAAAAGSGKLEERLYSVLCCTVCLDLPKASVYQCTNGHLMCAGCFIHLLADARLKEEQATCPNCRCEISKSLCCRNLAVEKAVSELPSECGFCLRQFPRSLLERHQKEECQDRVTQCKYKRIGCPWHGPFHELTVHEAACAHPTKTGSELMEILDGMDQSHRKEMQLYNSIFSLLSFEKIGYTEVQFRPYRTDDFITRLYYETPRFTVLNQTWVLKARVNDSERNPNLSCKRTLSFQLLLKSKVTAPLECSFLLLKGPYDDVRISPVIYHFVFTNESNETDYVPLPIIDSVECNKLLAAKNINLRLFLFQIQK

P0DTL6-1

  • Name
    1
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-124: MSGAEEAGGGGPAAGPAGSVPAGVGVGVGAGPGAAAGQAAAAALGEAAGPGLPDEAGLAGARQLQLQEAAGDPDAPPKKRLRAAEAAEAAAAAAAAGSGKLEERLYSVLCCTVCLDLPKASVYQ → MAPKPGAEWSTALSHLVLGVVSLHAAVSTAEASRGAAAGFLLQVLAATTTLAPGLSTHEDCLAGAWVATVIGLPLLAFDFHW

P0DTL6-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

P0DTL6-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-130: Missing
    • 275-333: EVQFRPYRTDDFITRLYYETPRFTVLNQTWVLKARVNDSERNPNLSCKRTLSFQLLLKS → GEAPRRLLHATQVWVGGLAARSLGAAGSGHWALTAPDSRALDKLPVDRWTPRSRRQAGD
    • 334-404: Missing

Sequence caution

The sequence BAD18724.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_0616331-124in isoform 1
Alternative sequenceVSP_0616321-130in isoform 4 and isoform 2
Alternative sequenceVSP_061634275-333in isoform 4
Alternative sequenceVSP_061635334-404in isoform 4

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB007965
EMBL· GenBank· DDBJ
-mRNA No translation available.
AK094514
EMBL· GenBank· DDBJ
BAG52882.1
EMBL· GenBank· DDBJ
mRNA
AK160381
EMBL· GenBank· DDBJ
BAD18724.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AC084125
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471162
EMBL· GenBank· DDBJ
EAW82088.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471162
EMBL· GenBank· DDBJ
EAW82089.1
EMBL· GenBank· DDBJ
Genomic DNA
BC004544
EMBL· GenBank· DDBJ
AAH04544.2
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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