P0DQJ8 · OCE1_LEPFX
- ProteinOcellatin-F1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Ocellatin-F1
Antibacterial peptide that inhibits reference strains of both Gram-negative bacteria (E.coli, P.aeruginosa, E.cloacae, K.pneumoniae, and A.actinomycetemcomitans) and Gram-positive bacteria (S.aureus) with relatively low potencies (MIC=25-400 uM) (By similarity) (PubMed:15544856).
Shows antifungal activity against C.lusitaniae (MIC=50.25 uM), but no activity against C.albicans (By similarity) (PubMed:15544856).
In the presence of an alkaloid (bufotenine), inhibits cellular infection by the rabies virus (By similarity).
The peptide shows very low hemolytic activity against rabbit erythrocytes (By similarity) (PubMed:15544856).
The low amphipathicity of alpha-helices demonstrated by wheel projection as well as the low cationicity may explain the low antibacterial and hemolytic potencies (Probable)
Shows antifungal activity against C.lusitaniae (MIC=50.25 uM), but no activity against C.albicans (By similarity) (PubMed:15544856).
In the presence of an alkaloid (bufotenine), inhibits cellular infection by the rabies virus (By similarity).
The peptide shows very low hemolytic activity against rabbit erythrocytes (By similarity) (PubMed:15544856).
The low amphipathicity of alpha-helices demonstrated by wheel projection as well as the low cationicity may explain the low antibacterial and hemolytic potencies (Probable)
Fallaxin(1-22)
Does not show activity against the microorganisms tested.
Miscellaneous
The primary structure of this peptide is identical to that of Ocellatin-F1 from Leptodactylus labyrinthicus (AC C0HKF0).
The cross-references to PDB can be found in this entry (AC C0HKF0).
The cross-references to PDB can be found in this entry (AC C0HKF0).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Biological Process | defense response to bacterium | |
Biological Process | defense response to fungus | |
Biological Process | hemolysis by symbiont of host erythrocytes | |
Biological Process | regulation of defense response to virus |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameOcellatin-F1
- Short namesOF1
- Alternative names
- Cleaved into 1 chains
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Neobatrachia > Hyloidea > Leptodactylidae > Leptodactylinae > Leptodactylus
Accessions
- Primary accessionP0DQJ8
Subcellular Location
PTM/Processing
Features
Showing features for peptide, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Peptide | PRO_0000449461 | 1-22 | Fallaxin(1-22) | ||
Peptide | PRO_0000449460 | 1-25 | Ocellatin-F1 | ||
Modified residue | 25 | Leucine amide | |||
Keywords
- PTM
Expression
Tissue specificity
Expressed by the skin glands.
Structure
Family & Domains
Sequence similarities
Belongs to the frog skin active peptide (FSAP) family. Ocellatin subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length25
- Mass (Da)2,549
- Last updated2020-04-22 v1
- Checksum3C42EAC8DE570755
Mass Spectrometry
Ocellatin-F1
Molecular mass is 2,546.6 Da. Determined by MALDI. Monoisotopic mass.Fallaxin(1-22)
Molecular mass is 2,193 Da. Determined by MALDI. Monoisotopic mass.Keywords
- Technical term