P0DQJ8 · OCE1_LEPFX

Function

function

Ocellatin-F1

Antibacterial peptide that inhibits reference strains of both Gram-negative bacteria (E.coli, P.aeruginosa, E.cloacae, K.pneumoniae, and A.actinomycetemcomitans) and Gram-positive bacteria (S.aureus) with relatively low potencies (MIC=25-400 uM) (By similarity) (PubMed:15544856).
Shows antifungal activity against C.lusitaniae (MIC=50.25 uM), but no activity against C.albicans (By similarity) (PubMed:15544856).
In the presence of an alkaloid (bufotenine), inhibits cellular infection by the rabies virus (By similarity).
The peptide shows very low hemolytic activity against rabbit erythrocytes (By similarity) (PubMed:15544856).
The low amphipathicity of alpha-helices demonstrated by wheel projection as well as the low cationicity may explain the low antibacterial and hemolytic potencies (Probable)

Fallaxin(1-22)

Does not show activity against the microorganisms tested.

Miscellaneous

The primary structure of this peptide is identical to that of Ocellatin-F1 from Leptodactylus labyrinthicus (AC C0HKF0).
The cross-references to PDB can be found in this entry (AC C0HKF0).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Biological Processdefense response to bacterium
Biological Processdefense response to fungus
Biological Processhemolysis by symbiont of host erythrocytes
Biological Processregulation of defense response to virus

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Ocellatin-F1
  • Short names
    OF1
  • Alternative names
    • Fallaxin
  • Cleaved into 1 chains
    • Fallaxin(1-22)
      Alternative names: Ocellatin-LB1

Organism names

Accessions

  • Primary accession
    P0DQJ8

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for peptide, modified residue.

Type
IDPosition(s)Description
PeptidePRO_00004494611-22Fallaxin(1-22)
PeptidePRO_00004494601-25Ocellatin-F1
Modified residue25Leucine amide

Keywords

Expression

Tissue specificity

Expressed by the skin glands.

Structure

Family & Domains

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    25
  • Mass (Da)
    2,549
  • Last updated
    2020-04-22 v1
  • Checksum
    3C42EAC8DE570755
GVVDILKGAAKDIAGHLASKVMNKL

Mass Spectrometry

Ocellatin-F1

Molecular mass is 2,546.6 Da. Determined by MALDI. Monoisotopic mass.

Fallaxin(1-22)

Molecular mass is 2,193 Da. Determined by MALDI. Monoisotopic mass.

Keywords

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help