P0DP79 · MDMY_MUSDO
- ProteinMale determiner protein Mdmd(Y)
- GeneMdmd
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1174 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Male determiner protein (M-factor) that controls male somatic sexual differentiation. Acts as a dominant factor that regulates the mRNA splicing of transformer (tra) and doublesex (dsx) transcripts and promotes expression of male splice forms of tra and dsx (By similarity).
Probably acts as a component of the spliceosome C complex required for mRNA splicing factor and exon-junction complex (EJC) assembly (By similarity).
Hinders eIF4AIII from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs (By similarity).
Probably acts as a component of the spliceosome C complex required for mRNA splicing factor and exon-junction complex (EJC) assembly (By similarity).
Hinders eIF4AIII from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs (By similarity).
Miscellaneous
The M.domestica genome only codes for one male determiner Mdmd protein, which is encoded in the M region, and can be located at different loci on the genome (chromosomes II, III, V or Y). The M region contains a cluster of tandemly repeated Mdmd copies with only one intact copy: other copies are degenerate with large truncations and frameshifts and are assumed to be non-functional. The presence of multiple copies in the M region may preserve its integrity in a hostile non-recombining environment. This protein is encoded on chromosome Y.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | catalytic step 2 spliceosome | |
Cellular Component | nuclear speck | |
Molecular Function | RNA binding | |
Biological Process | cell differentiation | |
Biological Process | male sex determination | |
Biological Process | male sex differentiation | |
Biological Process | mRNA splicing, via spliceosome | |
Biological Process | regulation of mRNA splicing, via spliceosome |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameMale determiner protein Mdmd(Y)
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Muscoidea > Muscidae > Musca
Accessions
- Primary accessionP0DP79
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000441324 | 1-1174 | Male determiner protein Mdmd(Y) | ||
Expression
Developmental stage
Specifically expressed in early male embryos. Zygotic expression first appears in 2- to 3-hour-old embryos (cellularized blastoderm stage). Expression is then maintained throughout male development until adulthood.
Interaction
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-51 | Disordered | |||
Compositional bias | 15-48 | Polar residues | |||
Region | 79-109 | Disordered | |||
Region | 136-259 | Disordered | |||
Compositional bias | 143-160 | Polar residues | |||
Compositional bias | 179-206 | Basic and acidic residues | |||
Compositional bias | 207-228 | Basic residues | |||
Compositional bias | 229-259 | Basic and acidic residues | |||
Domain | 348-531 | MIF4G | |||
Compositional bias | 597-613 | Polar residues | |||
Region | 597-616 | Disordered | |||
Domain | 641-757 | MI | |||
Compositional bias | 840-861 | Polar residues | |||
Region | 840-1045 | Disordered | |||
Compositional bias | 906-921 | Basic and acidic residues | |||
Compositional bias | 922-955 | Polar residues | |||
Compositional bias | 966-997 | Basic residues | |||
Compositional bias | 1009-1028 | Polar residues | |||
Region | 1089-1135 | Disordered | |||
Compositional bias | 1099-1119 | Basic and acidic residues | |||
Sequence similarities
Belongs to the CWC22 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,174
- Mass (Da)135,079
- Last updated2017-08-30 v1
- MD5 Checksum978747A506F20EDCCB9019C21787CA3F
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 15-48 | Polar residues | |||
Compositional bias | 143-160 | Polar residues | |||
Compositional bias | 179-206 | Basic and acidic residues | |||
Compositional bias | 207-228 | Basic residues | |||
Compositional bias | 229-259 | Basic and acidic residues | |||
Compositional bias | 597-613 | Polar residues | |||
Compositional bias | 840-861 | Polar residues | |||
Compositional bias | 906-921 | Basic and acidic residues | |||
Compositional bias | 922-955 | Polar residues | |||
Compositional bias | 966-997 | Basic residues | |||
Compositional bias | 1009-1028 | Polar residues | |||
Compositional bias | 1099-1119 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KY020047 EMBL· GenBank· DDBJ | ART29445.1 EMBL· GenBank· DDBJ | Genomic DNA |