P0DOX0 · C27C1_AQUCT

Function

function

Efficiently catalyzes the conversion of all-trans retinol (also called vitamin A1, the precursor of 11-cis retinal) to 3,4-didehydroretinol (also called vitamin A2, the precursor of 11-cis 3,4-didehydroretinal), also acts on all-trans retinal and all-trans retinoic acid. The replacement of 11-cis retinal chromophore in photopigments with 11-cis 3,4-didehydroretinal enhances sensitivity to long-wavelength light. This may improve vision in fresh water which is often turbid.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Features

Showing features for binding site.

153750100150200250300350400450500
TypeIDPosition(s)Description
Binding site483Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functionall-trans retinol 3,4-desaturase activity
Molecular Functionheme binding
Molecular Functioniron ion binding
Molecular Functionmonooxygenase activity
Biological Processlipid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome P450 27C1
  • EC number
  • Alternative names
    • All-trans retinol 3,4-desaturase

Gene names

    • Name
      cyp27c1

Organism names

Accessions

  • Primary accession
    P0DOX0

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004389131-537Cytochrome P450 27C1

Expression

Tissue specificity

Expressed in the dorsal third of retinal pigment epithelium, but not in the ventral counterpart (at protein level).

Structure

Family & Domains

Sequence similarities

Belongs to the cytochrome P450 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    537
  • Mass (Da)
    61,621
  • Last updated
    2017-02-15 v1
  • Checksum
    D8712BA2CD2CCF12
MLWQCWLQQAQRMRMMMKALLRFRATRLDSEMMGGWRRGAQRLAAGVVEGQRTLPQEGAAAGPRNLKEMPGPSTFRNLLEFFWRDGFSRIHEIQQNHIREYGRIFKSHFGPQFVVSIADRDMVAQILRAERDAPQRANMESWQEYRDLRGRSTGLISAEGKKWLAMRSVLRQKILRPRDVFIYAGGVNEVVSDLIKRIKTLRSREDDGETVTNVNDLYFKYSMEAVATILYECRLGCLQNEVPKQTLEYIEALELMFSMFKTTMYAGAIPKWLRPFIPKPWEEFCRSWDGLFRFSQIHVDGRLREIQACLDRGEEVKGGLLTSILISKELTLEELYANMTEMLLAGVDTTSFTLSWATYLLAKNPQAQQMVYDQIVQNLGKDTVPTAEDVPKLPLIRAVLKETLRLFPVLPGNGRVTQDDLVLGGYLIPKGTQLALCHYSTSYDQEYFTAAEDFQPGRWLRHGHLDRVENFGSIPFGYGIRSCIGKRVAELEIHLALIQLLQNFEIRTSPKTQTVLPKTHGLLCPAGAINVRFVNRE

Similar Proteins

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