P0DOX0 · C27C1_AQUCT
- ProteinCytochrome P450 27C1
- Genecyp27c1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids537 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Efficiently catalyzes the conversion of all-trans retinol (also called vitamin A1, the precursor of 11-cis retinal) to 3,4-didehydroretinol (also called vitamin A2, the precursor of 11-cis 3,4-didehydroretinal), also acts on all-trans retinal and all-trans retinoic acid. The replacement of 11-cis retinal chromophore in photopigments with 11-cis 3,4-didehydroretinal enhances sensitivity to long-wavelength light. This may improve vision in fresh water which is often turbid.
Catalytic activity
- all-trans-retinol + 2 H+ + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydroretinol + 2 H2O + 2 oxidized [adrenodoxin]
Cofactor
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | all-trans retinol 3,4-desaturase activity | |
Molecular Function | heme binding | |
Molecular Function | iron ion binding | |
Molecular Function | monooxygenase activity | |
Biological Process | lipid metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome P450 27C1
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Neobatrachia > Ranoidea > Ranidae > Aquarana
Accessions
- Primary accessionP0DOX0
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000438913 | 1-537 | Cytochrome P450 27C1 | |||
Sequence: MLWQCWLQQAQRMRMMMKALLRFRATRLDSEMMGGWRRGAQRLAAGVVEGQRTLPQEGAAAGPRNLKEMPGPSTFRNLLEFFWRDGFSRIHEIQQNHIREYGRIFKSHFGPQFVVSIADRDMVAQILRAERDAPQRANMESWQEYRDLRGRSTGLISAEGKKWLAMRSVLRQKILRPRDVFIYAGGVNEVVSDLIKRIKTLRSREDDGETVTNVNDLYFKYSMEAVATILYECRLGCLQNEVPKQTLEYIEALELMFSMFKTTMYAGAIPKWLRPFIPKPWEEFCRSWDGLFRFSQIHVDGRLREIQACLDRGEEVKGGLLTSILISKELTLEELYANMTEMLLAGVDTTSFTLSWATYLLAKNPQAQQMVYDQIVQNLGKDTVPTAEDVPKLPLIRAVLKETLRLFPVLPGNGRVTQDDLVLGGYLIPKGTQLALCHYSTSYDQEYFTAAEDFQPGRWLRHGHLDRVENFGSIPFGYGIRSCIGKRVAELEIHLALIQLLQNFEIRTSPKTQTVLPKTHGLLCPAGAINVRFVNRE |
Expression
Tissue specificity
Expressed in the dorsal third of retinal pigment epithelium, but not in the ventral counterpart (at protein level).
Structure
Sequence
- Sequence statusComplete
- Length537
- Mass (Da)61,621
- Last updated2017-02-15 v1
- ChecksumD8712BA2CD2CCF12