P0DOJ5 · LT_POVM3
- ProteinLarge T antigen
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids782 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
Cofactor
Features
Showing features for dna binding, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 293-407 | T-ag OBD | ||||
Sequence: PSSLTGYLSHAIYSNKTFPAFLVYSTKEKCKQLYDTIGKFRPEFKCLVHYEEGGMLFFLTMTKHRVSAVKNYCSKLCSVSFLMCKAVTKPMECYQVVTAAPFQLITENKPGLHQF | ||||||
Binding site | 453 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 456 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 466 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 470 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 575-582 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GPVNSGKT |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | host cell nucleus | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | DNA replication origin binding | |
Molecular Function | helicase activity | |
Molecular Function | isomerase activity | |
Molecular Function | metal ion binding | |
Biological Process | DNA replication | |
Biological Process | symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint | |
Biological Process | symbiont-mediated suppression of host innate immune response | |
Biological Process | symbiont-mediated suppression of host JAK-STAT cascade via inhibition of JAK1 activity | |
Biological Process | symbiont-mediated suppression of host type I interferon-mediated signaling pathway | |
Biological Process | virus-mediated perturbation of host defense response |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLarge T antigen
- EC number
- Short namesLT; LT-AG
- Alternative names
Organism names
- Taxonomic lineageViruses > Monodnaviria > Shotokuvirae > Cossaviricota > Papovaviricetes > Sepolyvirales > Polyomaviridae > Alphapolyomavirus > Mus musculus polyomavirus 1
- Virus hosts
Accessions
- Primary accessionP0DOJ5
- Secondary accessions
Proteomes
Subcellular Location
Phenotypes & Variants
Keywords
- Disease
PTM/Processing
Features
Showing features for modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Modified residue | 1 | N-acetylmethionine; by host | ||||
Sequence: M | ||||||
Chain | PRO_0000442782 | 1-782 | Large T antigen | |||
Sequence: MDRVLSRADKERLLELLKLPRQLWGDFGRMQQAYKQQSLLLHPDKGGSHALMQELNSLWGTFKTEVYNLRMNLGGTGFQGSPPRTAERGTEESGHSPLHDDYWSFSYGSKYFTREWNDFFRKWDPSYQSPPKTAESSEQPDLFCYEEPLLSPNPSSPTDTPAHTAGRRRNPCVAEPDDSISPDPPRTPVSRKRPRPAGATGGGGGGVHANGGSVFGHPTGGTSTPAHPPPYHSQGGSESMGGSDSSGFAEGSFRSDPRCESENESYSQSCSQSSFNATPPKKAREDPAPSDFPSSLTGYLSHAIYSNKTFPAFLVYSTKEKCKQLYDTIGKFRPEFKCLVHYEEGGMLFFLTMTKHRVSAVKNYCSKLCSVSFLMCKAVTKPMECYQVVTAAPFQLITENKPGLHQFEFTDEPEEQKAVDWIMVADFALENNLDDPLLIMGYYLDFAKEVPSCIKCSKEETRLQIHWKNHRKHAENADLFLNCKAQKTICQQAADGVLASRRLKLVECTRSQLLKERLQQSLLRLKELGSSDALLYLAGVAWYQCLLEDFPQTLFKMLKLLTENVPKRRNILFRGPVNSGKTGLAAALISLLGGKSLNINCPADKLAFELGVAQDQFVVCFEDVKGQIALNKQLQPGMGVANLDNLRDYLDGSVKVNLEKKHSNKRSQLFPPCVCTMNEYLLPQTVWARFHMVLDFTCKPHLAQSLEKCEFLQRERIIQSGDTLALLLIWNFTSDVFDPDIQGLVKEVRDQFASECSYSLFCDILCNVQEGDDPLKDICEYS | ||||||
Modified residue | 278 | Phosphothreonine; by host | ||||
Sequence: T |
Post-translational modification
Keywords
- PTM
Expression
Keywords
- Developmental stage
Interaction
Subunit
Family & Domains
Features
Showing features for domain, region, motif, compositional bias, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 12-75 | J | ||||
Sequence: RLLELLKLPRQLWGDFGRMQQAYKQQSLLLHPDKGGSHALMQELNSLWGTFKTEVYNLRMNLGG | ||||||
Region | 74-97 | Disordered | ||||
Sequence: GGTGFQGSPPRTAERGTEESGHSP | ||||||
Motif | 142-146 | LXCXE motif | ||||
Sequence: LFCYE | ||||||
Region | 145-291 | Disordered | ||||
Sequence: YEEPLLSPNPSSPTDTPAHTAGRRRNPCVAEPDDSISPDPPRTPVSRKRPRPAGATGGGGGGVHANGGSVFGHPTGGTSTPAHPPPYHSQGGSESMGGSDSSGFAEGSFRSDPRCESENESYSQSCSQSSFNATPPKKAREDPAPSD | ||||||
Compositional bias | 216-250 | Polar residues | ||||
Sequence: GHPTGGTSTPAHPPPYHSQGGSESMGGSDSSGFAE | ||||||
Compositional bias | 262-279 | Polar residues | ||||
Sequence: ENESYSQSCSQSSFNATP | ||||||
Motif | 279-286 | Nuclear localization signal | ||||
Sequence: PPKKARED | ||||||
Zinc finger | 416-510 | T-ag D1-type | ||||
Sequence: QKAVDWIMVADFALENNLDDPLLIMGYYLDFAKEVPSCIKCSKEETRLQIHWKNHRKHAENADLFLNCKAQKTICQQAADGVLASRRLKLVECTR | ||||||
Domain | 549-709 | SF3 helicase | ||||
Sequence: DFPQTLFKMLKLLTENVPKRRNILFRGPVNSGKTGLAAALISLLGGKSLNINCPADKLAFELGVAQDQFVVCFEDVKGQIALNKQLQPGMGVANLDNLRDYLDGSVKVNLEKKHSNKRSQLFPPCVCTMNEYLLPQTVWARFHMVLDFTCKPHLAQSLEKC |
Domain
Keywords
- Domain
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
P0DOJ5-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameLarge T antigen
- Length782
- Mass (Da)87,662
- Last updated2017-12-20 v1
- Checksum5E24E1F8A586C7A9
P0DOJ8-1
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- NameMiddle T antigen
P68834-1
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- NameSmall t antigen
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 216-250 | Polar residues | ||||
Sequence: GHPTGGTSTPAHPPPYHSQGGSESMGGSDSSGFAE | ||||||
Compositional bias | 262-279 | Polar residues | ||||
Sequence: ENESYSQSCSQSSFNATP |
Keywords
- Coding sequence diversity
- Technical term