P0DOF7 · M1_I72A8

Function

function

Plays critical roles in virus replication, from virus entry and uncoating to assembly and budding of the virus particle. M1 binding to ribonucleocapsids (RNPs) in nucleus seems to inhibit viral transcription. Interaction of viral NEP with M1-RNP is thought to promote nuclear export of the complex, which is targeted to the virion assembly site at the apical plasma membrane in polarized epithelial cells. Interactions with NA and HA may bring M1, a non-raft-associated protein, into lipid rafts. Forms a continuous shell on the inner side of the lipid bilayer in virion, where it binds the RNP. During virus entry into cell, the M2 ion channel acidifies the internal virion core, inducing M1 dissociation from the RNP. M1-free RNPs are transported to the nucleus, where viral transcription and replication can take place.
Determines the virion's shape: spherical or filamentous. Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology. Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.

Miscellaneous

Most abundant protein in virion. When expressed alone can form virus-like particles in transfected cells.

GO annotations

AspectTerm
Cellular Componenthost cell nucleus
Cellular Componentmembrane
Cellular Componentvirion membrane
Molecular FunctionRNA binding
Molecular Functionstructural constituent of virion
Biological Processviral budding from plasma membrane

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Matrix protein 1
  • Short names
    M1

Gene names

    • Name
      M

Organism names

Accessions

  • Primary accession
    P0DOF7
  • Secondary accessions
    • P03486
    • P10919
    • P63233
    • Q1K9D7

Proteomes

Subcellular Location

Virion membrane
; Peripheral membrane protein
Host nucleus

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis41No effect on filamentous virion particles morphology.
Mutagenesis95Complete loss of filamentous virion particles morphology.
Mutagenesis167No effect on filamentous virion particles morphology.
Mutagenesis168No effect on filamentous virion particles morphology.
Mutagenesis204Complete loss of filamentous virion particles morphology.
Mutagenesis205No effect on filamentous virion particles morphology.
Mutagenesis218No effect on filamentous virion particles morphology.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000788661-252Matrix protein 1

Interaction

Subunit

Homodimer and homomultimer. Interacts with NEP. Binds ribonucleocapsid by both interacting with genomic RNA and NP protein. May interact with HA and NA. Cannot bind NP without genomic RNA.

Structure

3D structure databases

Family & Domains

Features

Showing features for region, motif.

TypeIDPosition(s)Description
Region1-164Membrane-binding
Motif101-105Nuclear localization signal
Region165-252RNP-binding

Sequence similarities

Belongs to the influenza viruses Matrix protein M1 family.

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing. Only the first 9 residues are shared by the 2 isoforms.

P0DOF7-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    252
  • Mass (Da)
    27,804
  • Last updated
    2017-05-10 v1
  • Checksum
    92522D3E87D4C3C6
MSLLTEVETYVLSIVPSGPLKAEIAQRLEDVFAGKNTDLEALMEWLKTRPILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDRAVKLYRKLKREITFHGAKEIALSYSAGALASCMGLIYNRMGAVTTEVAFGLVCATCEQIADSQHRSHRQMVATTNPLIRHENRMVLASTTAKAMEQMAGSSEQAAEAMEVASQARQMVQAMRAIGTHPSSSAGLKDDLLENLQAYQKRMGVQMQRFK

P0DOF8-1

The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

View isoform

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
J02167
EMBL· GenBank· DDBJ
AAA43304.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

Disclaimer

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