P0DOB2 · GEDH_ASPTN

Function

function

Anthrone oxygenase; part of the gene cluster that mediates the biosynthesis of geodin, an intermediate in the biosynthesis of other natural products (PubMed:19549600, PubMed:24009710, PubMed:7665560).
The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) gedC (PubMed:12536215, PubMed:19549600).
The atrochrysone carboxyl ACP thioesterase gedB then breaks the thioester bond and releases the atrochrysone carboxylic acid from gedC (PubMed:19549600).
The atrochrysone carboxylic acid is then converted to atrochrysone which is further transformed into emodin anthrone (PubMed:24009710).
The next step is performed by the emodin anthrone oxygenase gedH that catalyzes the oxidation of emodinanthrone to emodin (PubMed:1810248).
Emodin O-methyltransferase encoded probably by gedA then catalyzes methylation of the 8-hydroxy group of emodin to form questin (PubMed:1444712).
Ring cleavage of questin by questin oxidase gedK leads to desmethylsulochrin via several intermediates including questin epoxide (PubMed:3182756).
Another methylation step probably catalyzed by methyltransferase gedG leads to the formation of sulochrin which is further converted to dihydrogeodin by the sulochrin halogenase gedL (PubMed:24009710).
Finally, the dihydrogeodin oxidase gedJ catalyzes the stereospecific phenol oxidative coupling reaction converting dihydrogeodin to geodin (PubMed:7665560).

Catalytic activity

Pathway

Secondary metabolite biosynthesis.

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functionmonooxygenase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Anthrone oxygenase gedH
  • EC number
  • Alternative names
    • Geodin synthesis protein H

Gene names

    • Name
      gedH
    • ORF names
      ATEG_08457-2

Organism names

Accessions

  • Primary accession
    P0DOB2
  • Secondary accessions
    • Q0CCX7

Proteomes

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane1-21Helical
Transmembrane41-61Helical
Transmembrane73-93Helical
Transmembrane128-148Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004370961-150Anthrone oxygenase gedH

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the anthrone oxygenase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    150
  • Mass (Da)
    16,271
  • Last updated
    2016-09-07 v1
  • Checksum
    6036551E65A78341
MANPAVGAMMGLSLVAVPVFLDTNTQSEQLLAQFASLYDYGHKLMPTIAVATCALHGWVAARKRAAHQPWGRPVLAAVTTITMVPFTWVCMVSTNNALFQLHKGADANMEMVRALIARWQWLHVARSLFPLAGAIVACQTLLKELVGGSR

Sequence caution

The sequence EAU31630.1 differs from that shown. Reason: Erroneous gene model prediction The predicted gene ATEG_08457 has been split into 2 genes: ATEG_08457-1 and ATEG_08457-2.
The sequence EAU31630.1 differs from that shown. Reason: Erroneous translation

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH476605
EMBL· GenBank· DDBJ
EAU31630.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.

Similar Proteins

Disclaimer

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