P0DOA7 · ESXV_MYCTU

Function

function

Probable virulence factor. In mice, elicits increased levels of IFN-gamma, IL-12 and IgG(2a), indicating a dominant Th1 host immune response.

Miscellaneous

Potent T-cell antigen that could be a subunit vaccine candidate.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Cellular Componentpeptidoglycan-based cell wall

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    ESAT-6-like protein EsxV
  • Alternative names
    • Antigen Mtb9.9B

Gene names

    • Name
      esxV
    • ORF names
      MTCY07H7B.03, MTCY15C10.33
    • Ordered locus names
      Rv3619c

Organism names

Accessions

  • Primary accession
    P0DOA7
  • Secondary accessions
    • L0TEQ6
    • O08120
    • O08122
    • P96364
    • P9WNK1
    • Q9L781

Proteomes

Organism-specific databases

Subcellular Location

Secreted
Note: Probably secreted via the ESX-5 / type VII secretion system (T7SS) (Probable). May bind to lipid membranes after dissociation of the complex (Probable).

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004369281-94ESAT-6-like protein EsxV

Interaction

Subunit

Forms a tight 1:1 complex with EsxW. The complex is destabilized at low pH. Unfolding of the proteins is required for dissociation of the complex and membrane binding.

Structure

Family & Domains

Sequence similarities

Belongs to the WXG100 family. ESAT-6 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    94
  • Mass (Da)
    9,833
  • Last updated
    2016-09-07 v1
  • Checksum
    8F971BB03789C57E
MTINYQFGDVDAHGAMIRAQAGSLEAEHQAIISDVLTASDFWGGAGSAACQGFITQLGRNFQVIYEQANAHGQKVQAAGNNMAQTDSAVGSSWA

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict20in Ref. 1; AAF32406
Sequence conflict23in Ref. 1; AAF32406

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF226277
EMBL· GenBank· DDBJ
AAF32406.1
EMBL· GenBank· DDBJ
Genomic DNA
AL123456
EMBL· GenBank· DDBJ
CCP46442.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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