P0DN71 · SIRTM_STRPG
- ProteinProtein ADP-ribosyltransferase
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids293 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Catalyzes specifically the mono-ADP-ribosylation of GcvH-L (SpyM50867). This activity is dependent on prior lipoylation of the target protein. May be involved in the modulation of the response to host-derived oxidative stress. In contrast to other sirtuin classes, lacks protein deacylase activity, being unable to catalyze debiotinylation, deacetylation and desuccinylation of proteins.
Miscellaneous
The SirTM-mediated ADP-ribosylation can be specifically reversed by the Macro domain-containing protein encoded by the same operon (SpyM50868).
Catalytic activity
- L-aspartyl-[protein] + NAD+ = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 34 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: A | ||||||
Binding site | 117-120 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: TNAD | ||||||
Binding site | 137 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 145 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 149 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 180 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 183 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 232-234 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: HTT | ||||||
Binding site | 258 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 262 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 279 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: I |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | NAD+ binding | |
Molecular Function | NAD+-protein ADP-ribosyltransferase activity | |
Molecular Function | nucleotidyltransferase activity | |
Molecular Function | zinc ion binding |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein ADP-ribosyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Streptococcaceae > Streptococcus
Accessions
- Primary accessionP0DN71
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 118 | Loss of catalytic activity. | ||||
Sequence: N → A | ||||||
Mutagenesis | 137 | Loss of catalytic activity. | ||||
Sequence: Q → H or T | ||||||
Mutagenesis | 192 | Dramatic decrease in catalytic activity. | ||||
Sequence: R → A |
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000435344 | 1-293 | Protein ADP-ribosyltransferase | |||
Sequence: MSNWTTYPQKNLTQAEQLAQLIKEADALVVGIGAGMSAADGFTYIGPRFETAFPDFIAKYQFLDMLQASLFDFEDWQEYWAFQSRFVALNYLDQPVGQSYLDLKEILETKDYHIITTNADNAFWVAGYDPHNIFHIQGEYGLWQCSQHCHQQTYKDDTVIRQMIAEQKNMKVPGQLIPHCPECEAPFEINKRNEEKGMVEDADFHAQKARYEAFLSEHKEGKVLYLEIGVGHTTPQFIKHPFWKRVSENPNALFVTLNHKHYRIPLSIRRQSLELTEHIAQLISATKTIYQKS |
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 8-292 | Deacetylase sirtuin-type | ||||
Sequence: PQKNLTQAEQLAQLIKEADALVVGIGAGMSAADGFTYIGPRFETAFPDFIAKYQFLDMLQASLFDFEDWQEYWAFQSRFVALNYLDQPVGQSYLDLKEILETKDYHIITTNADNAFWVAGYDPHNIFHIQGEYGLWQCSQHCHQQTYKDDTVIRQMIAEQKNMKVPGQLIPHCPECEAPFEINKRNEEKGMVEDADFHAQKARYEAFLSEHKEGKVLYLEIGVGHTTPQFIKHPFWKRVSENPNALFVTLNHKHYRIPLSIRRQSLELTEHIAQLISATKTIYQK |
Sequence similarities
Belongs to the sirtuin family. Class M subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length293
- Mass (Da)33,985
- Last updated2016-01-20 v1
- Checksum8A98CFC27EA1B944
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AM295007 EMBL· GenBank· DDBJ | CAM30197.1 EMBL· GenBank· DDBJ | Genomic DNA |