P0DN68 · LEXA_FIBSS
- ProteinLexA repressor
- GenelexA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids217 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Probably represses a number of genes involved in the response to DNA damage (SOS response), including itself, recA, uvrA, ruvAB and ssb (PubMed:15528664).
The probable consensus LexA box is 5'-TGCAC-N4-GTGCA-3' (PubMed:15528664).
In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (Probable)
The probable consensus LexA box is 5'-TGCAC-N4-GTGCA-3' (PubMed:15528664).
In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (Probable)
Catalytic activity
Features
Showing features for dna binding, site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 35-55 | H-T-H motif | ||||
Sequence: VREIGNHFDISSTNGVRSILA | ||||||
Site | 101-102 | Cleavage; by autolysis | ||||
Sequence: AG | ||||||
Active site | 137 | For autocatalytic cleavage activity | ||||
Sequence: S | ||||||
Active site | 174 | For autocatalytic cleavage activity | ||||
Sequence: K |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | protein-DNA complex | |
Molecular Function | sequence-specific DNA binding | |
Molecular Function | serine-type endopeptidase activity | |
Biological Process | DNA repair | |
Biological Process | DNA replication | |
Biological Process | negative regulation of DNA-templated transcription | |
Biological Process | proteolysis | |
Biological Process | SOS response |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLexA repressor
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Fibrobacterota > Fibrobacteria > Fibrobacterales > Fibrobacteraceae > Fibrobacter
Accessions
- Primary accessionP0DN68
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000435132 | 1-217 | LexA repressor | |||
Sequence: MENTNEKRKEMTARQEEIYEYIKKYSKENHMPPTVREIGNHFDISSTNGVRSILAALIKKGYINRSPRLSRGIEILSDDKESSKEVASNTIEIPIVGRVAAGTPILAVQNLEGTVTIDRDFLACRSDVFALRVKGDSMINAGIFDGDLIFARQQKTADLGEIVVAQIDNEATVKYYHPSADHVELRPANPKYKPIIVNNRKDFSIAGRVIGVMRKVN |
Keywords
- PTM
Expression
Gene expression databases
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length217
- Mass (Da)24,288
- Last updated2015-12-09 v1
- ChecksumC831385424BD34FF