P0DN28 · APOC3_HORSE

  • Protein
    Apolipoprotein C-III
  • Gene
    APOC3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners.

Features

Showing features for site.

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MQPRVLLIAALLALLATAAEDKDASLLDVVQGYMQQASKTAKDTLTSMQESQVAQQARDWVNDGLSSLKDYWGKLKGKFSSFWDSTFEDTTPSPAVA
TypeIDPosition(s)Description
Site39May interact with the LDL receptor

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchylomicron
Cellular Componentintermediate-density lipoprotein particle
Cellular Componentspherical high-density lipoprotein particle
Cellular Componentvery-low-density lipoprotein particle
Molecular Functionhigh-density lipoprotein particle receptor binding
Molecular Functionlipase inhibitor activity
Molecular Functionphospholipid binding
Biological Processcholesterol homeostasis
Biological Processlipid catabolic process
Biological Processlipid transport
Biological Processlipoprotein metabolic process
Biological Processnegative regulation of high-density lipoprotein particle clearance
Biological Processnegative regulation of low-density lipoprotein particle clearance
Biological Processnegative regulation of triglyceride catabolic process
Biological Processnegative regulation of very-low-density lipoprotein particle clearance
Biological Processtriglyceride homeostasis

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Apolipoprotein C-III
  • Short names
    Apo-CIII; ApoC-III
  • Alternative names
    • Apolipoprotein C3

Gene names

    • Name
      APOC3

Organism names

  • Taxonomic identifier
  • Strain
    • Mongolian
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Equidae > Equus

Accessions

  • Primary accession
    P0DN28

Proteomes

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-18
ChainPRO_000043395919-97Apolipoprotein C-III

Keywords

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region66-97Lipid-binding

Sequence similarities

Belongs to the apolipoprotein C3 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    97
  • Mass (Da)
    10,598
  • Last updated
    2015-10-14 v1
  • Checksum
    23EF2A4FEBF0F591
MQPRVLLIAALLALLATAAEDKDASLLDVVQGYMQQASKTAKDTLTSMQESQVAQQARDWVNDGLSSLKDYWGKLKGKFSSFWDSTFEDTTPSPAVA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ATDM01002572
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Similar Proteins

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