P0DMA9 · APOA1_PHYMC

Function

function

Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendocytic vesicle
Cellular Componentspherical high-density lipoprotein particle
Cellular Componentvery-low-density lipoprotein particle
Molecular Functionamyloid-beta binding
Molecular Functionapolipoprotein A-I receptor binding
Molecular Functionchemorepellent activity
Molecular Functioncholesterol binding
Molecular Functioncholesterol transfer activity
Molecular Functionenzyme binding
Molecular Functionheat shock protein binding
Molecular Functionhigh-density lipoprotein particle binding
Molecular Functionhigh-density lipoprotein particle receptor binding
Molecular Functionphosphatidylcholine-sterol O-acyltransferase activator activity
Molecular Functionphospholipid binding
Molecular Functionprotein homodimerization activity
Biological Processadrenal gland development
Biological Processblood vessel endothelial cell migration
Biological Processcholesterol biosynthetic process
Biological Processcholesterol efflux
Biological Processcholesterol homeostasis
Biological Processcholesterol import
Biological Processendothelial cell proliferation
Biological ProcessG protein-coupled receptor signaling pathway
Biological Processglucocorticoid metabolic process
Biological Processhigh-density lipoprotein particle assembly
Biological Processhigh-density lipoprotein particle remodeling
Biological Processintegrin-mediated signaling pathway
Biological Processlipid storage
Biological Processlipoprotein biosynthetic process
Biological Processnegative regulation of cell adhesion molecule production
Biological Processnegative regulation of cytokine production involved in immune response
Biological Processnegative regulation of heterotypic cell-cell adhesion
Biological Processnegative regulation of inflammatory response
Biological Processnegative regulation of interleukin-1 beta production
Biological Processnegative regulation of tumor necrosis factor-mediated signaling pathway
Biological Processnegative regulation of very-low-density lipoprotein particle remodeling
Biological Processphosphatidylcholine biosynthetic process
Biological Processphospholipid efflux
Biological Processphospholipid homeostasis
Biological Processpositive regulation of cholesterol efflux
Biological Processpositive regulation of cholesterol metabolic process
Biological Processpositive regulation of phagocytosis
Biological Processpositive regulation of phospholipid efflux
Biological Processpositive regulation of Rho protein signal transduction
Biological Processpositive regulation of stress fiber assembly
Biological Processpositive regulation of substrate adhesion-dependent cell spreading
Biological Processprotein stabilization
Biological Processregulation of Cdc42 protein signal transduction
Biological Processregulation of intestinal cholesterol absorption
Biological Processregulation of protein phosphorylation
Biological Processreverse cholesterol transport
Biological Processtriglyceride homeostasis
Biological Processvitamin transport

Keywords

Names & Taxonomy

Protein names

Gene names

    • Name
      APOA1

Organism names

Accessions

  • Primary accession
    P0DMA9

Proteomes

PTM/Processing

Features

Showing features for signal, chain, modified residue.

TypeIDPosition(s)Description
Signal1-18
ChainPRO_000042533319-265Proapolipoprotein A-I
ChainPRO_000042509925-264Truncated apolipoprotein A-I
ChainPRO_000042509825-265Apolipoprotein A-I
Modified residue109Methionine sulfoxide

Post-translational modification

Glycosylated.
Palmitoylated.
Phosphorylation sites are present in the extracellular medium.

Keywords

Expression

Tissue specificity

Major protein of plasma HDL, also found in chylomicrons.

Interaction

Subunit

Homodimer (By similarity).
Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1. Interacts with SCGB3A2 (By similarity).
Interacts with NAXE and YJEFN3 (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for repeat, region.

TypeIDPosition(s)Description
Repeat67-881
Region67-26510 X approximate tandem repeats
Repeat89-1102
Repeat111-1213; half-length
Repeat122-1424
Repeat144-1655
Repeat166-1876
Repeat188-2097
Repeat210-2308
Repeat231-2419; half-length
Repeat242-26510

Sequence similarities

Belongs to the apolipoprotein A1/A4/E family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    265
  • Mass (Da)
    30,434
  • Last updated
    2014-01-22 v1
  • Checksum
    10AB7EED7F18D9E3
MKALVLTLAVLFFTGSQAQHFWQQDDPQSSWDRVKDFATVYVDAIKDSGRDYVAQFEASALGKQLNLKLLDNWDSLTSTFAKVREQLGPVTQEFWDNLEKETESLRQEMNKDLEEVKQKVQPYLDEFKRKWQEELQIYRQKVAPLGEELREGARQKVQELQDKLTPLAEEMRDRARAHVETLRQQLAPYSDDLRQRMATRFEVLKEGGGSLAEYHAKASEQLKALGEKAKPALEDLRQGLLPVLESLKVSILAAIDEASKKLNAQ

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2Y9F8Y2A0A2Y9F8Y2_PHYMCAPOA1265

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AWZP01054823
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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