P0DMA8 · APOA1_PANHO
- ProteinApolipoprotein A-I
- GeneAPOA1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids262 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | high-density lipoprotein particle | |
Molecular Function | lipid binding | |
Molecular Function | protein homodimerization activity | |
Biological Process | cholesterol metabolic process | |
Biological Process | lipid transport | |
Biological Process | lipoprotein metabolic process | |
Biological Process | positive regulation of cholesterol efflux | |
Biological Process | positive regulation of phagocytosis | |
Biological Process | positive regulation of phospholipid efflux | |
Biological Process | protein stabilization |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameApolipoprotein A-I
- Short namesApo-AI; ApoA-I
- Alternative names
- Cleaved into 2 chains
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Antilopinae > Pantholops
Accessions
- Primary accessionP0DMA8
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-18 | |||||
Sequence: MKAVVLTLAVLFLTGSQA | ||||||
Chain | PRO_0000425331 | 19-262 | Proapolipoprotein A-I | |||
Sequence: RHFWQQDEPQSSWDRVKDFATVYVEAIKDSGRDYVAQFEASALGKQLNLKLLDNWDTLASTLSKVREQLGPVTQEFWDNLEKETAALRQEMNKDLEEVKQKVQPYLDEFQRKWHEEVEIYRQKVAPLGEEFREGARQKVQELQDRLSPLAQELRDRARAHVEKQLAPYSDDLRQRLTARLEALKEGGGSLAEYHAKATEQLKALGEKAKPALEDLRQGLMPVLESLKVSILAAIDEASKKLNAQ | ||||||
Chain | PRO_0000425096 | 25-261 | Truncated apolipoprotein A-I | |||
Sequence: DEPQSSWDRVKDFATVYVEAIKDSGRDYVAQFEASALGKQLNLKLLDNWDTLASTLSKVREQLGPVTQEFWDNLEKETAALRQEMNKDLEEVKQKVQPYLDEFQRKWHEEVEIYRQKVAPLGEEFREGARQKVQELQDRLSPLAQELRDRARAHVEKQLAPYSDDLRQRLTARLEALKEGGGSLAEYHAKATEQLKALGEKAKPALEDLRQGLMPVLESLKVSILAAIDEASKKLNA | ||||||
Chain | PRO_0000425095 | 25-262 | Apolipoprotein A-I | |||
Sequence: DEPQSSWDRVKDFATVYVEAIKDSGRDYVAQFEASALGKQLNLKLLDNWDTLASTLSKVREQLGPVTQEFWDNLEKETAALRQEMNKDLEEVKQKVQPYLDEFQRKWHEEVEIYRQKVAPLGEEFREGARQKVQELQDRLSPLAQELRDRARAHVEKQLAPYSDDLRQRLTARLEALKEGGGSLAEYHAKATEQLKALGEKAKPALEDLRQGLMPVLESLKVSILAAIDEASKKLNAQ | ||||||
Modified residue | 109 | Methionine sulfoxide | ||||
Sequence: M | ||||||
Modified residue | 238 | Methionine sulfoxide | ||||
Sequence: M |
Post-translational modification
Glycosylated.
Palmitoylated.
Phosphorylation sites are present in the extracellular medium.
Keywords
- PTM
Expression
Tissue specificity
Major protein of plasma HDL, also found in chylomicrons.
Interaction
Subunit
Homodimer (By similarity).
Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1. Interacts with SCGB3A2 (By similarity).
Interacts with NAXE and YJEFN3 (By similarity).
Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1. Interacts with SCGB3A2 (By similarity).
Interacts with NAXE and YJEFN3 (By similarity).
Structure
Family & Domains
Features
Showing features for repeat, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 67-88 | 1 | ||||
Sequence: LKLLDNWDTLASTLSKVREQLG | ||||||
Region | 67-262 | 10 X approximate tandem repeats | ||||
Sequence: LKLLDNWDTLASTLSKVREQLGPVTQEFWDNLEKETAALRQEMNKDLEEVKQKVQPYLDEFQRKWHEEVEIYRQKVAPLGEEFREGARQKVQELQDRLSPLAQELRDRARAHVEKQLAPYSDDLRQRLTARLEALKEGGGSLAEYHAKATEQLKALGEKAKPALEDLRQGLMPVLESLKVSILAAIDEASKKLNAQ | ||||||
Repeat | 89-110 | 2 | ||||
Sequence: PVTQEFWDNLEKETAALRQEMN | ||||||
Repeat | 111-121 | 3; half-length | ||||
Sequence: KDLEEVKQKVQ | ||||||
Repeat | 122-142 | 4 | ||||
Sequence: PYLDEFQRKWHEEVEIYRQKV | ||||||
Repeat | 144-165 | 5 | ||||
Sequence: PLGEEFREGARQKVQELQDRLS | ||||||
Repeat | 166-184 | 6 | ||||
Sequence: PLAQELRDRARAHVEKQLA | ||||||
Repeat | 185-206 | 7 | ||||
Sequence: PYSDDLRQRLTARLEALKEGGG | ||||||
Repeat | 207-227 | 8 | ||||
Sequence: SLAEYHAKATEQLKALGEKAK | ||||||
Repeat | 228-238 | 9; half-length | ||||
Sequence: PALEDLRQGLM | ||||||
Repeat | 239-262 | 10 | ||||
Sequence: PVLESLKVSILAAIDEASKKLNAQ |
Sequence similarities
Belongs to the apolipoprotein A1/A4/E family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length262
- Mass (Da)29,941
- Last updated2014-01-22 v1
- Checksum2BDF5E99FBFBAF13