P0DL79 · TXP1B_BRASM

Function

function

Inhibits voltage-gated calcium channels (Cav) in rat cerebellar granule cells (By similarity).
Has insecticidal activity (By similarity).

Miscellaneous

The primary structure of the mature peptide is identical to that of Eurypelma spider toxin 2 from Aphonopelma californicum (AC P61510).

Caution

It is reported in PubMed:11790834 that disulfide bonds may be in positions 4-17, 8-31 and 25-36.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Molecular Functiontoxin activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Omega-theraphotoxin-Bs1b
  • Short names
    Omega-TRTX-Bs1b
  • Alternative names
    • BsTX1b
    • Venom protein 1

Organism names

Accessions

  • Primary accession
    P0DL79
  • Secondary accessions
    • P49265

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for peptide, disulfide bond.

TypeIDPosition(s)Description
PeptidePRO_00004422331-39Omega-theraphotoxin-Bs1b
Disulfide bond4↔25
Disulfide bond8↔31
Disulfide bond17↔36

Keywords

Expression

Tissue specificity

Expressed by the venom gland.

Structure

Family & Domains

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    39
  • Mass (Da)
    4,371
  • Last updated
    2017-11-22 v1
  • Checksum
    2672A54E64993DB2
IIECVFSCDIEKEGKPCKPKGEKKCSGGWKCKIKLCLKI

Mass Spectrometry

Molecular mass is 4,400.4 Da. Determined by Electrospray.

Keywords

Similar Proteins

Disclaimer

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