P0DL67 · O16A_CONSC

Function

function

This toxin activates voltage-gated sodium channels (Nav1.3/SCN3A (EC50=3.98 nM), Nav1.4/SCN4A (EC50=4.99 nM), Nav1.6/SCN8A (EC50=1.27 nM) and Nav1.7/SCN9A (EC50=2.42 nM)). It shifts the voltage-dependence of activation to more hyperpolarized potentials but has only little effect on channel inactivation. In vivo, it induces nocifensive or pain-like behaviors in mice when injected intraplantarly. This is coherent with the specific defensive role deduced from its proximal position in the venom gland.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Molecular Functionsodium channel regulator activity
Molecular Functiontoxin activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Delta-conotoxin SuVIA
  • Short names
    Delta-SuVIA

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Lophotrochozoa > Mollusca > Gastropoda > Caenogastropoda > Neogastropoda > Conoidea > Conidae > Conus > Tesselliconus

Accessions

  • Primary accession
    P0DL67

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for disulfide bond, peptide.

TypeIDPosition(s)Description
Disulfide bond1↔17
PeptidePRO_00004398271-27Delta-conotoxin SuVIA
Disulfide bond8↔21
Disulfide bond16↔25

Keywords

Expression

Tissue specificity

Expressed by the venom duct, in the proximal part (indicative of a defensive role).

Structure

Family & Domains

Domain

The cysteine framework is VI/VII (C-C-CC-C-C).
The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Sequence similarities

Belongs to the conotoxin O1 superfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    27
  • Mass (Da)
    2,749
  • Last updated
    2017-05-10 v1
  • Checksum
    4ED9DEF2FBB14BBA
CAGIGSFCGLPGLVDCCSDRCFIVCLP

Mass Spectrometry

Molecular mass is 2,741.16 Da. Determined by MALDI. Monoisotopic mass.

Keywords

Similar Proteins

Disclaimer

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