P0DKU5 · APOC2_COLGU

Function

function

Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchylomicron
Cellular Componentintermediate-density lipoprotein particle
Cellular Componentlow-density lipoprotein particle
Cellular Componentspherical high-density lipoprotein particle
Cellular Componentvery-low-density lipoprotein particle
Molecular Functionlipid binding
Molecular Functionlipoprotein lipase activator activity
Molecular Functionphospholipase activator activity
Molecular Functionphospholipase binding
Biological Processchylomicron remnant clearance
Biological Processhigh-density lipoprotein particle clearance
Biological Processlipid catabolic process
Biological Processlipid transport
Biological Processnegative regulation of very-low-density lipoprotein particle clearance
Biological Processpositive regulation of phospholipid catabolic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Apolipoprotein C-II
  • Short names
    Apo-CII; ApoC-II
  • Alternative names
    • Apolipoprotein C2
  • Cleaved into 1 chains

Gene names

    • Name
      APOC2

Organism names

Accessions

  • Primary accession
    P0DKU5

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-22
ChainPRO_000042089723-101Proapolipoprotein C-II
ChainPRO_000043083829-101Apolipoprotein C-II

Post-translational modification

Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing.
Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma.

Keywords

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region66-74Lipid binding
Region78-101Lipoprotein lipase cofactor

Sequence similarities

Belongs to the apolipoprotein C2 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    101
  • Mass (Da)
    11,120
  • Last updated
    2013-02-06 v1
  • Checksum
    4C0BB6EC88BCF6E0
MGTRFLLALCLVLLVLGFEVQGAQLSQQDEPPSPALLTQVQESLSSYWESAKAAAQKLYQKTYLPAVDEKLRDLYSKSTAAMSTYTGIFTDQVLSVLKGEE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC148222
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Similar Proteins

Disclaimer

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