P0DKQ3 · M7E_CONCN

Function

function

Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav).

Miscellaneous

Found in injectable (milked) (IV) venom.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Molecular Functioncalcium channel regulator activity
Molecular Functionion channel inhibitor activity
Molecular Functiontoxin activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Omega-conotoxin-like CnVIIE
  • Cleaved into 1 chains

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Lophotrochozoa > Mollusca > Gastropoda > Caenogastropoda > Neogastropoda > Conoidea > Conidae > Conus > Pionoconus

Accessions

  • Primary accession
    P0DKQ3
  • Secondary accessions
    • S6CQC0

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, propeptide, disulfide bond, peptide, modified residue.

TypeIDPosition(s)Description
Signal1-22
PropeptidePRO_000045177423-45
Disulfide bond46↔61
PeptidePRO_000041988446-70Omega-conotoxin-like CnVIIC
PeptidePRO_000041988346-71Omega-conotoxin-like CnVIIE
Modified residue524-hydroxyproline; partial
Disulfide bond53↔65
Disulfide bond60↔70
Modified residue70Cysteine amide

Keywords

Expression

Tissue specificity

Expressed by the venom duct.

Structure

Family & Domains

Domain

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
The cysteine framework is VI/VII (C-C-CC-C-C).

Sequence similarities

Belongs to the conotoxin M superfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    71
  • Mass (Da)
    7,569
  • Last updated
    2021-02-10 v2
  • Checksum
    3B133D8567DD1BC0
MKLTCVVIVAVLLLTACQLITADDSRGTQKHRALRSDTKLSMSTRCKGTGKPCSRIAYNCCTGSCRSGKCG

Mass Spectrometry

Omega-conotoxin-like CnVIIE

Molecular mass is 2,649.06 Da. Determined by Electrospray. CnVIIE.

Omega-conotoxin-like CnVIIC

Molecular mass is 2,575.052 Da. Determined by Electrospray. CnVIIC.

Omega-conotoxin-like CnVIIC

Molecular mass is 2,591.03 Da. Determined by Electrospray. [Hyp7]-CnVIIC.

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HE856385
EMBL· GenBank· DDBJ
CCI55498.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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