P0DKQ3 · M7E_CONCN
- ProteinOmega-conotoxin-like CnVIIE
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav).
Miscellaneous
Found in injectable (milked) (IV) venom.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Molecular Function | calcium channel regulator activity | |
Molecular Function | ion channel inhibitor activity | |
Molecular Function | toxin activity |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameOmega-conotoxin-like CnVIIE
- Cleaved into 1 chains
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Spiralia > Lophotrochozoa > Mollusca > Gastropoda > Caenogastropoda > Neogastropoda > Conoidea > Conidae > Conus > Pionoconus
Accessions
- Primary accessionP0DKQ3
- Secondary accessions
Subcellular Location
PTM/Processing
Features
Showing features for signal, propeptide, disulfide bond, peptide, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-22 | |||||
Sequence: MKLTCVVIVAVLLLTACQLITA | ||||||
Propeptide | PRO_0000451774 | 23-45 | ||||
Sequence: DDSRGTQKHRALRSDTKLSMSTR | ||||||
Disulfide bond | 46↔61 | |||||
Sequence: CKGTGKPCSRIAYNCC | ||||||
Peptide | PRO_0000419884 | 46-70 | Omega-conotoxin-like CnVIIC | |||
Sequence: CKGTGKPCSRIAYNCCTGSCRSGKC | ||||||
Peptide | PRO_0000419883 | 46-71 | Omega-conotoxin-like CnVIIE | |||
Sequence: CKGTGKPCSRIAYNCCTGSCRSGKCG | ||||||
Modified residue | 52 | 4-hydroxyproline; partial | ||||
Sequence: P | ||||||
Disulfide bond | 53↔65 | |||||
Sequence: CSRIAYNCCTGSC | ||||||
Disulfide bond | 60↔70 | |||||
Sequence: CCTGSCRSGKC | ||||||
Modified residue | 70 | Cysteine amide | ||||
Sequence: C |
Keywords
- PTM
Expression
Tissue specificity
Expressed by the venom duct.
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length71
- Mass (Da)7,569
- Last updated2021-02-10 v2
- Checksum3B133D8567DD1BC0