P0DKH3 · RI2BL_ARATH

Function

function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Caution

In cv. Columbia, could be the product of a pseudogene (AC P0DKH2) due to a frameshift in position 140. The resulting shorter protein lacks the conserved features of the family.

Catalytic activity

Cofactor

Fe cation (UniProtKB | Rhea| CHEBI:24875 )

Note: Binds 2 iron ions per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site76Fe cation 1 (UniProtKB | ChEBI)
Binding site107Fe cation 1 (UniProtKB | ChEBI)
Binding site107Fe cation 2 (UniProtKB | ChEBI)
Binding site110Fe cation 1 (UniProtKB | ChEBI)
Active site114
Binding site169Fe cation 2 (UniProtKB | ChEBI)
Binding site203Fe cation 2 (UniProtKB | ChEBI)
Binding site206Fe cation 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmetal ion binding
Molecular Functionribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
Biological Processdeoxyribonucleotide biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribonucleoside-diphosphate reductase small chain B
  • EC number
  • Alternative names
    • Ribonucleoside-diphosphate reductase R2B subunit
    • Ribonucleotide reductase small subunit B

Gene names

    • Name
      RNR2B

Organism names

  • Taxonomic identifier
  • Strains
    • cv. Landsberg erecta
    • cv. Wassilewskija
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    P0DKH3
  • Secondary accessions
    • Q6Y657
    • Q84W71

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

No visible phenotype, due to the redundancy with RNR2A and TSO2. Rnr2a and rnr2b double mutants have no visible phenotype.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004304641-333Ribonucleoside-diphosphate reductase small chain B

Expression

Tissue specificity

Expressed in roots, rosette leaves, stems and flowers.

Gene expression databases

Interaction

Subunit

Heterodimer of a large and a small chain.

Structure

Family & Domains

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    333
  • Mass (Da)
    38,331
  • Last updated
    2014-10-01 v1
  • Checksum
    CA20B044F92DB922
MPSMPEEPILTPTPDRFCMFPIQYPQIWEMYKKAEASFWTAEEVDLSQDNRDWENSLTNDERHFIKHVLAFFAASDGIVLENLSTRFMSDVQISEARAFYGFQIAIENIHSEMYSLLLDTYIKDNKERDHLFRAIETIPCVTKKAEWAMKWINGSQSFAERIVAFACVEGIFFSGSFCSIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLIYSLLRTKLDEDRLKAIVCDAVEIEREFVCDALPCALVGMNRELMSQYIEFVADRLLAALGCAKVYGVSNPFDWMELISLQGKTNFFEKRVGEYQKASIMSSVHGNAAFNDDHVFKLDEDF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY178109
EMBL· GenBank· DDBJ
AAO62422.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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