P0DKB8 · LPXC3_ARATH

Function

function

Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell. Lipid A-like molecules in plants may serve as structural components of the outer membranes of mitochondria and/or chloroplasts, or may be involved in signal transduction or plant defense responses (Potential).

Miscellaneous

Plants silencing LPXC do not have altered morphology compared to wild-type plants when grown under normal growth conditions, but they do not accumulate 2,3-diacylglucosamine-1-phosphate.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site109Zn2+ (UniProtKB | ChEBI)
Binding site281Zn2+ (UniProtKB | ChEBI)
Binding site285Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrion
Molecular Functionmetal ion binding
Molecular FunctionUDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Molecular FunctionUDP-3-O-acyl-N-acetylglucosamine deacetylase activity
Biological Processlipid A biosynthetic process
Biological Processlipid X metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable UDP-3-O-acyl-N-acetylglucosamine deacetylase 3, mitochondrial
  • EC number
  • Short names
    UDP-3-O-acyl-GlcNAc deacetylase 3
  • Alternative names
    • Protein LIPID X C3 (AtLpxC3)
    • UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase 3

Gene names

    • Name
      LPXC3
    • ORF names
      F5A9.8
    • Ordered locus names
      At1g25054

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    P0DKB8
  • Secondary accessions
    • B3H6R1
    • E2RTM8
    • P0C2G7
    • Q56X64
    • Q56XG5

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for transit peptide, chain.

TypeIDPosition(s)Description
Transit peptide1-21Mitochondrion
ChainPRO_000041965922-326Probable UDP-3-O-acyl-N-acetylglucosamine deacetylase 3, mitochondrial

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the LpxC family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 1 isoforms produced by Alternative splicing. A number of isoforms are produced. According to EST sequences.

P0DKB8-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    326
  • Mass (Da)
    35,717
  • Last updated
    2012-10-03 v1
  • Checksum
    CBF391A5DFB4EEA9
MRLPVTVKATKPSFLVIWIRYSSAASSPTVSLNPSGRLQQTLAGSVEVKGKSLHSGKFSTVKLNPEIAGAGRFFEFRSRFIPASIEFAQESPLCTTLLKDELKIRTVEHLLSALEAKGVDNCRIQIESESSDDREVEVPIFDGSAKEWVDAIQGVGINAAQNHDGESVEKMVAHVNKPVYVCKNDTFVAAFPALETRITCGIDFPQVPAIGCQWFSWRPIHESSFAKDIASSRTFCVYEEVERMREAGLIKGGSLDNAIVCSAEHGWMNPPLRFDDEACRHKILDLIGDLSLVSRGGNGGLPVAHIVAYKAGHALHTDLARHLTMD

Sequence caution

The sequence AAG03128.1 differs from that shown. Reason: Erroneous gene model prediction The predicted gene has been split into 2 genes: At1g25054 and At1g25055.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC004133
EMBL· GenBank· DDBJ
AAG03128.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002684
EMBL· GenBank· DDBJ
AEE30573.2
EMBL· GenBank· DDBJ
Genomic DNA
AK118128
EMBL· GenBank· DDBJ
BAC42754.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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