P0DJ43 · VM3_MICIK
- ProteinZinc metalloproteinase-disintegrin-like mikarin
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids169 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Snake venom zinc metalloproteinase that calcium-independently catalyzes the conversion of prothrombin (F2) to alpha-thrombin through the formation of a thrombin intermediate.
Miscellaneous
Negative results: does not have an affect on factor X (F10) and fibrinogen.
Cofactor
Note: Binds 1 zinc ion per subunit.
Activity regulation
Inhibited by EDTA, but not by PMSF.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Cellular Component | host extracellular space | |
Cellular Component | plasma membrane | |
Molecular Function | metal ion binding | |
Molecular Function | metalloendopeptidase activity | |
Molecular Function | peptidase activator activity | |
Molecular Function | toxin activity | |
Biological Process | induction of blood coagulation in another organism | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameZinc metalloproteinase-disintegrin-like mikarin
- EC number
- Alternative names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Lepidosauria > Squamata > Bifurcata > Unidentata > Episquamata > Toxicofera > Serpentes > Colubroidea > Elapidae > Notechinae > Micropechis
Accessions
- Primary accessionP0DJ43
Subcellular Location
PTM/Processing
Features
Showing features for chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000418035 | 1-169 | Zinc metalloproteinase-disintegrin-like mikarin | |||
Sequence: TNTPEQDRYLQVKKYLEYVVVDNNMYRNYGNAGPCVMSAEISFEPLQEFSSCDIQEPLSQDIVQPAVCGNYYVEVGGECDCGSPKPCRSACCNAATCKLQREHQCDSGECCEKKDDCDLPEICTGRSAKCSCVISQGDLGYGMVEPGTKCTDGMVCSNEQCVDVQTAAK | ||||||
Disulfide bond | 68↔97 | |||||
Sequence: CGNYYVEVGGECDCGSPKPCRSACCNAATC | ||||||
Disulfide bond | 79↔92 | |||||
Sequence: CDCGSPKPCRSACC | ||||||
Disulfide bond | 81↔87 | |||||
Sequence: CGSPKPC | ||||||
Disulfide bond | 105↔111 | |||||
Sequence: CDSGECC | ||||||
Disulfide bond | 110↔123 | |||||
Sequence: CCEKKDDCDLPEIC | ||||||
Disulfide bond | 150↔161 | |||||
Sequence: CTDGMVCSNEQC |
Keywords
- PTM
Expression
Tissue specificity
Expressed by the venom gland.
Interaction
Subunit
Monomer.
Structure
Family & Domains
Features
Showing features for domain, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 14-57 | Peptidase M12B | ||||
Sequence: KYLEYVVVDNNMYRNYGNAGPCVMSAEISFEPLQEFSSCDIQEP | ||||||
Domain | 65-129 | Disintegrin | ||||
Sequence: PAVCGNYYVEVGGECDCGSPKPCRSACCNAATCKLQREHQCDSGECCEKKDDCDLPEICTGRSAK | ||||||
Motif | 116-118 | D/ECD-tripeptide | ||||
Sequence: DCD |
Sequence similarities
Family and domain databases
Sequence
- Sequence statusFragments
- Length169
- Mass (Da)18,439
- Last updated2012-06-13 v1
- Checksum29E83FDA889EEE40
Features
Showing features for non-adjacent residues.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-adjacent residues | 30-31 | |||||
Sequence: GN | ||||||
Non-adjacent residues | 57-58 | |||||
Sequence: PL | ||||||
Non-adjacent residues | 113-114 | |||||
Sequence: KK | ||||||
Non-adjacent residues | 129-130 | |||||
Sequence: KC |
Keywords
- Technical term