P0CZ01 · HYLB_CUTAK

Function

function

Degrades hyaluronic acid (HA) exclusively into HA disaccharides (HA-2). Produced HA-2s confer anti-inflammatory properties leading to reduced immunopathology in the mouse model of acne.

Catalytic activity

Features

Showing features for active site.

1813100200300400500600700800
TypeIDPosition(s)Description
Active site222
Active site272
Active site281

GO annotations

AspectTerm
Cellular Componentextracellular region
Molecular Functioncarbohydrate binding
Molecular Functionhyaluronate lyase activity
Biological Processcarbohydrate metabolic process

Keywords

Enzyme and pathway databases

Protein family/group databases

    • PL8Polysaccharide Lyase Family 8

Names & Taxonomy

Protein names

  • Recommended name
    Hyaluronate lyase HylB
  • EC number
  • Alternative names
    • Hyaluronidase
      (HYase)

Gene names

    • Name
      hylB
    • Ordered locus names
      PPA0380

Organism names

Accessions

  • Primary accession
    P0CZ01
  • Secondary accessions
    • Q59634
    • Q6AAT4

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-32Tat-type signal
ChainPRO_000002493033-813Hyaluronate lyase HylB

Post-translational modification

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

Structure

Family & Domains

Sequence similarities

Belongs to the polysaccharide lyase 8 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    813
  • Mass (Da)
    88,130
  • Last updated
    2011-06-28 v1
  • Checksum
    0C4316E7890D4D1D
MFGTPSRRTFLTASALSAMALAASPTVTDAIAAPGPDSWSALCERWIDIITGRRAARTSDPRARAIIAKTDRKVAEILTDLVSGSSRQTVLISADLRKEQSPFITKTARAIESMACAWATPGSSYHKDPEILSACIEGLRDFCRLRYNPSQDEYGNWWDWEDGASRAVADVMCILHDVLPPEVMSAAAAGIDHFIPDPWFQQPASVKPTANPVQPVVSTGANRMDLTRAVMCRSIATGDEKRLRHAVDGLPDAWRVTTEGDGFRADGGFIQHSHIPYTGGYGDVLFSGLAMLFPLVSGMRFDIVESARKAFHDQVERGFIPVMYNGQILDDVRGRSISRINESAAMHGISIARAMLMMADALPTHRAEQWRGIVHGWMARNTFDHLSEPSTLVDISLFDAAAKARPVPESSTPSYFASMDRLVHRTADWLITVSNCSDRIAWYEYGNGENEWASRTSQGMRYLLLPGDMGQYEDGYWATVDYSAPTGTTVDSTPLKRAVGASWAAKTPTNEWSGGLASGSWSAAASHITSQDSALKARRLWVGLKDAMVELTTDVTTDASRAITVVEHRKVASSSTKLLVDGNRVSSATSFQNPRWAHLDGVGGYVFATDTDLSADVATRKGTWIDVNPSRKVKGADEVIERAYASLHVTHHDRPVAWALLPTASRSHTMALATRPGVEPFTVLRNDATVQAVRSAGALLTKDPTVVTTLAFWKPATCGGVAVNRPALVQTRESANQMEVVIVEPTQKRGSLTVTIEGSWKVKTADSHVDVSCENAAGTLHVDTAGLGGQSVRVTLARQVTQTPSGGGRHDRA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE017283
EMBL· GenBank· DDBJ
AAT82132.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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