P0CY10 · MATA1_YEASX
- ProteinMating-type protein A1
- GeneMATA1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids126 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional corepressor that, in a/alpha diploid cells, binds cooperatively with the ALPHA2 protein to a 21-bp DNA sequence termed the haploid-specific gene (hsg) operator, to repress transcription of haploid-specific genes and of MATALPHA1.
Miscellaneous
Was initially thought to be alternatively spliced.
This gene is functional with 1, 2 or no introns, but the functional protein is produced only when both introns are spliced from the mRNA.
There are three genetic loci for mating type genes in S.cerevisiae. MAT is the expression locus that determines the mating type of the cell, whereas HML (containing HMLALPHA1 and HMLALPHA2) and HMR (containing HMRA1 and HMRA2) represent silenced repositories of mating type information. The mating type is determined by the MAT locus, which contains either a copy of HML or of HMR. Diploid cells are usually heterozygous for the MAT locus.
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 70-126 | Homeobox | ||||
Sequence: SPKGKSSISPQARAFLEQVFRRKQSLNSKEKEEVAKKCGITPLQVRVWFINKRMRSK |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | transcription corepressor activity | |
Biological Process | regulation of mating-type specific transcription, DNA-templated |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameMating-type protein A1
- Short namesMATa1 protein
Gene names
Organism names
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP0CY10
- Secondary accessions
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000049201 | 1-126 | Mating-type protein A1 | |||
Sequence: MDDICSMAENINRTLFNILGTEIDEINLNTNNLYNFIMESNLTKVEQHTLHKNISNNRLEIYHHIKKEKSPKGKSSISPQARAFLEQVFRRKQSLNSKEKEEVAKKCGITPLQVRVWFINKRMRSK |
Expression
Developmental stage
Only present in a-cells and in a/alpha diploid cells.
Structure
Sequence
- Sequence statusComplete
- Length126
- Mass (Da)14,803
- Last updated2011-06-28 v1
- ChecksumB413D0042EB97B3A
Sequence caution
Keywords
- Technical term