P0CY10 · MATA1_YEASX

Function

function

Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional corepressor that, in a/alpha diploid cells, binds cooperatively with the ALPHA2 protein to a 21-bp DNA sequence termed the haploid-specific gene (hsg) operator, to repress transcription of haploid-specific genes and of MATALPHA1.

Miscellaneous

Was initially thought to be alternatively spliced.
This gene is functional with 1, 2 or no introns, but the functional protein is produced only when both introns are spliced from the mRNA.
There are three genetic loci for mating type genes in S.cerevisiae. MAT is the expression locus that determines the mating type of the cell, whereas HML (containing HMLALPHA1 and HMLALPHA2) and HMR (containing HMRA1 and HMRA2) represent silenced repositories of mating type information. The mating type is determined by the MAT locus, which contains either a copy of HML or of HMR. Diploid cells are usually heterozygous for the MAT locus.

Features

Showing features for dna binding.

1126102030405060708090100110120
TypeIDPosition(s)Description
DNA binding70-126Homeobox

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Functiontranscription corepressor activity
Biological Processregulation of mating-type specific transcription, DNA-templated

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Mating-type protein A1
  • Short names
    MATa1 protein

Gene names

    • Name
      MATA1
    • Synonyms
      MAT1A

Organism names

Accessions

  • Primary accession
    P0CY10
  • Secondary accessions
    • D6VR98
    • P01366
    • P09091
    • Q06724

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000492011-126Mating-type protein A1

Expression

Developmental stage

Only present in a-cells and in a/alpha diploid cells.

Interaction

Subunit

Binds DNA with a high specificity as a heterodimer of A1 and ALPHA2.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the MATA1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    126
  • Mass (Da)
    14,803
  • Last updated
    2011-06-28 v1
  • Checksum
    B413D0042EB97B3A
MDDICSMAENINRTLFNILGTEIDEINLNTNNLYNFIMESNLTKVEQHTLHKNISNNRLEIYHHIKKEKSPKGKSSISPQARAFLEQVFRRKQSLNSKEKEEVAKKCGITPLQVRVWFINKRMRSK

Sequence caution

The sequence CAA24622.1 differs from that shown. Reason: Erroneous gene model prediction
The sequence Ref.2 differs from that shown. Reason: Erroneous gene model prediction

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
V01313
EMBL· GenBank· DDBJ
CAA24622.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
V01312
EMBL· GenBank· DDBJ
CAA24619.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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