P0CW42 · FWDC_METMI

Function

function

Catalyzes the reversible oxidation of CO2 and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.

Catalytic activity

Pathway

One-carbon metabolism; methanogenesis from CO2; 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO2: step 1/3.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functionformylmethanofuran dehydrogenase activity
Molecular Functiontransition metal ion binding
Biological Processmethanogenesis, from carbon dioxide

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tungsten-containing formylmethanofuran dehydrogenase 2 subunit C
  • EC number
  • Alternative names
    • Tungsten-containing formylmethanofuran dehydrogenase II subunit C

Gene names

    • Name
      fwdC

Organism names

Accessions

  • Primary accession
    P0CW42
  • Secondary accessions
    • O31112

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001441951-272Tungsten-containing formylmethanofuran dehydrogenase 2 subunit C

Interaction

Subunit

This enzyme is composed of seven subunits fwdA (65 kDa), fwdB (53 kDa), fwdC (31 kDa), fwdD (15 kDa), fwdE, fwdF and fwdG.

Structure

Family & Domains

Features

Showing features for repeat, region.

TypeIDPosition(s)Description
Repeat77-891
Region77-2107 X 13 AA repeats of [GW]-X-X-[MLP]-X-X-G-X-[IL]-X-[IV]-X-G
Repeat96-1082
Repeat115-1273
Repeat141-1534
Repeat160-1725
Repeat179-1916
Repeat198-2107

Sequence similarities

Belongs to the FwdC/FmdC family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    272
  • Mass (Da)
    29,174
  • Last updated
    2011-05-03 v1
  • Checksum
    50912BD8B47A4BF0
MNELILNLKGDVSVPVEMDKIIPEKIQEMSLEKISGIELIQGNKTAKVSEIFDVELKESPVSKVTINNCCKKVKRIGEKMTSGEIVVNGDAGMYVGVEMKGGKITVNGDAESWVGQNLKGGEIIINGNAENYVGSAYRGDWRGMSGGKITITGTAGSELGEYLKGGTIVIKGNTKIMPGIHPNGGMIIIEGDIEGRAGGEMMKGAIVVYGKTLEPLPSFKFEGIVEDPLVKLFKKDAGTQLKGTFIKFSGDYVNTKPKGQLYAAIENNKNLI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF029842
EMBL· GenBank· DDBJ
AAB82591.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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