P0CS95 · PYRE_CRYNJ
- ProteinOrotate phosphoribosyltransferase
- GeneURA5
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids225 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
Catalytic activity
- orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate
Pathway
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 31 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain | |||
Binding site | 39-40 | orotate (UniProtKB | ChEBI) | |||
Binding site | 78-79 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain | |||
Binding site | 105 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners | |||
Binding site | 106 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain | |||
Binding site | 109 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners | |||
Binding site | 111 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners | |||
Binding site | 130-138 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain | |||
Binding site | 134 | orotate (UniProtKB | ChEBI) | |||
Binding site | 163 | orotate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | orotate phosphoribosyltransferase activity | |
Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | |
Biological Process | 'de novo' UMP biosynthetic process | |
Biological Process | pyrimidine nucleotide biosynthetic process | |
Biological Process | pyrimidine ribonucleoside biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOrotate phosphoribosyltransferase
- EC number
- Short namesOPRT; OPRTase
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Tremellomycetes > Tremellales > Cryptococcaceae > Cryptococcus > Cryptococcus neoformans species complex
Accessions
- Primary accessionP0CS95
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Natural variant | 8 | in strain: J21 | |||
Natural variant | 11 | in strain: J15, J17, J24, J25, C5, C7, C24, E4, E9, E12, 184 and ATCC 24064 | |||
Natural variant | 57 | in strain: J26 and J19 | |||
Natural variant | 69 | in strain: J25 | |||
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 4 variants from UniProt as well as other sources including ClinVar and dbSNP.
Miscellaneous
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000110796 | 1-225 | Orotate phosphoribosyltransferase | ||
Proteomic databases
Interaction
Structure
Sequence
- Sequence statusComplete
- Length225
- Mass (Da)24,419
- Last updated2013-02-06 v1
- ChecksumA36EEF8D54CDEB81
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M34606 EMBL· GenBank· DDBJ | AAA33076.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
L38582 EMBL· GenBank· DDBJ | AAA99182.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
L38583 EMBL· GenBank· DDBJ | AAA99183.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
L38584 EMBL· GenBank· DDBJ | AAA99184.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
L38585 EMBL· GenBank· DDBJ | AAA99185.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
L38586 EMBL· GenBank· DDBJ | AAA99186.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
L38587 EMBL· GenBank· DDBJ | AAA99187.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
L38588 EMBL· GenBank· DDBJ | AAA99188.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U67723 EMBL· GenBank· DDBJ | AAB17140.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U67724 EMBL· GenBank· DDBJ | AAB17141.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U67725 EMBL· GenBank· DDBJ | AAB17142.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U67726 EMBL· GenBank· DDBJ | AAB17143.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U67728 EMBL· GenBank· DDBJ | AAB17145.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U67730 EMBL· GenBank· DDBJ | AAB17147.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U67731 EMBL· GenBank· DDBJ | AAB17148.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF032430 EMBL· GenBank· DDBJ | AAB86885.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF032432 EMBL· GenBank· DDBJ | AAB86887.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF032434 EMBL· GenBank· DDBJ | AAB86889.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ555829 EMBL· GenBank· DDBJ | CAD88485.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE017347 EMBL· GenBank· DDBJ | AAW44772.1 EMBL· GenBank· DDBJ | Genomic DNA |