P0CS95 · PYRE_CRYNJ

Function

function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).

Catalytic activity

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.

Features

Showing features for binding site.

122520406080100120140160180200220
TypeIDPosition(s)Description
Binding site315-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site39-40orotate (UniProtKB | ChEBI)
Binding site78-795-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site1055-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site1065-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site1095-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site1115-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site130-1385-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site134orotate (UniProtKB | ChEBI)
Binding site163orotate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionorotate phosphoribosyltransferase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process
Biological Processpyrimidine nucleotide biosynthetic process
Biological Processpyrimidine ribonucleoside biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Orotate phosphoribosyltransferase
  • EC number
  • Short names
    OPRT; OPRTase

Gene names

    • Name
      URA5
    • Ordered locus names
      CNG03730

Organism names

Accessions

  • Primary accession
    P0CS95
  • Secondary accessions
    • P0CQ40
    • P18132
    • Q55PW2
    • Q5KDJ6

Proteomes

Organism-specific databases

Subcellular Location

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant8in strain: J21
Natural variant11in strain: J15, J17, J24, J25, C5, C7, C24, E4, E9, E12, 184 and ATCC 24064
Natural variant57in strain: J26 and J19
Natural variant69in strain: J25

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 4 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Miscellaneous

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001107961-225Orotate phosphoribosyltransferase

Proteomic databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    225
  • Mass (Da)
    24,419
  • Last updated
    2013-02-06 v1
  • Checksum
    A36EEF8D54CDEB81
MSSQALDSAKVAFIEAAIEHGVLLFGNFTLKSGRQSPYFFNAGLLYSSSLLSTTAQAYAKVLSSSRIPDFDVLFGPAYKGISLAAVSAVSLYQQTGKDIGYCYNRKEKKDHGEGGTMVGAPLKGRIVIIDDVLTSGKAIREAIDILKASPEAKLVGIVQLVDRQEKGQSGSGKSTVQEVEEEFGVPVEPIIGLDDIVKYLESSGKWEKELQEVRKYRAEYGVQRS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M34606
EMBL· GenBank· DDBJ
AAA33076.1
EMBL· GenBank· DDBJ
Genomic DNA
L38582
EMBL· GenBank· DDBJ
AAA99182.1
EMBL· GenBank· DDBJ
Genomic DNA
L38583
EMBL· GenBank· DDBJ
AAA99183.1
EMBL· GenBank· DDBJ
Genomic DNA
L38584
EMBL· GenBank· DDBJ
AAA99184.1
EMBL· GenBank· DDBJ
Genomic DNA
L38585
EMBL· GenBank· DDBJ
AAA99185.1
EMBL· GenBank· DDBJ
Genomic DNA
L38586
EMBL· GenBank· DDBJ
AAA99186.1
EMBL· GenBank· DDBJ
Genomic DNA
L38587
EMBL· GenBank· DDBJ
AAA99187.1
EMBL· GenBank· DDBJ
Genomic DNA
L38588
EMBL· GenBank· DDBJ
AAA99188.1
EMBL· GenBank· DDBJ
Genomic DNA
U67723
EMBL· GenBank· DDBJ
AAB17140.1
EMBL· GenBank· DDBJ
Genomic DNA
U67724
EMBL· GenBank· DDBJ
AAB17141.1
EMBL· GenBank· DDBJ
Genomic DNA
U67725
EMBL· GenBank· DDBJ
AAB17142.1
EMBL· GenBank· DDBJ
Genomic DNA
U67726
EMBL· GenBank· DDBJ
AAB17143.1
EMBL· GenBank· DDBJ
Genomic DNA
U67728
EMBL· GenBank· DDBJ
AAB17145.1
EMBL· GenBank· DDBJ
Genomic DNA
U67730
EMBL· GenBank· DDBJ
AAB17147.1
EMBL· GenBank· DDBJ
Genomic DNA
U67731
EMBL· GenBank· DDBJ
AAB17148.1
EMBL· GenBank· DDBJ
Genomic DNA
AF032430
EMBL· GenBank· DDBJ
AAB86885.1
EMBL· GenBank· DDBJ
Genomic DNA
AF032432
EMBL· GenBank· DDBJ
AAB86887.1
EMBL· GenBank· DDBJ
Genomic DNA
AF032434
EMBL· GenBank· DDBJ
AAB86889.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ555829
EMBL· GenBank· DDBJ
CAD88485.1
EMBL· GenBank· DDBJ
Genomic DNA
AE017347
EMBL· GenBank· DDBJ
AAW44772.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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