P0CR64 · SNX41_CRYNJ
- ProteinSorting nexin-41
- GeneSNX41
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids638 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
May be required for cytoplasm to vacuole transport (Cvt) and pexophagy.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 118 | a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) (UniProtKB | ChEBI) | |||
Binding site | 120 | a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) (UniProtKB | ChEBI) | |||
Binding site | 144 | a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) (UniProtKB | ChEBI) | |||
Binding site | 168 | a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | endosome membrane | |
Molecular Function | phosphatidylinositol binding | |
Biological Process | autophagy | |
Biological Process | protein transport | |
Biological Process | retrograde transport, endosome to Golgi |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameSorting nexin-41
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Tremellomycetes > Tremellales > Cryptococcaceae > Cryptococcus > Cryptococcus neoformans species complex
Accessions
- Primary accessionP0CR64
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endosome membrane ; Peripheral membrane protein
Endomembrane system ; Peripheral membrane protein
Note: Endosome and other perivacuolar punctate structures.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000213827 | 1-638 | Sorting nexin-41 | ||
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-69 | Disordered | |||
Compositional bias | 11-32 | Pro residues | |||
Domain | 84-201 | PX | |||
Region | 215-239 | Disordered | |||
Compositional bias | 217-239 | Polar residues | |||
Region | 408-432 | Disordered | |||
Region | 545-638 | Disordered | |||
Compositional bias | 548-574 | Polar residues | |||
Compositional bias | 576-598 | Basic and acidic residues | |||
Domain
The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization to the perivacuolar punctate structures.
Sequence similarities
Belongs to the sorting nexin family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length638
- Mass (Da)70,714
- Last updated2011-06-28 v1
- MD5 Checksum5F17C01875D5A3445BDA9AA43144C189
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 11-32 | Pro residues | |||
Compositional bias | 217-239 | Polar residues | |||
Compositional bias | 548-574 | Polar residues | |||
Compositional bias | 576-598 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE017343 EMBL· GenBank· DDBJ | AAW42383.2 EMBL· GenBank· DDBJ | Genomic DNA | Different initiation |