P0CR30 · SAR1_CRYNJ

Function

function

Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. SAR1 controls the coat assembly in a stepwise manner. Activated SAR1-GTP binds to membranes first and recruits the SEC23/24 complex. These SEC23/24-SAR1 prebudding intermediates are then collected by the SEC13/31 complex as subunits polymerize to form coated transport vesicles. Conversion to SAR1-GDP triggers coat release and recycles COPII subunits (By similarity).

Catalytic activity

Features

Showing features for binding site.

118920406080100120140160180
TypeIDPosition(s)Description
Binding site27-34GTP (UniProtKB | ChEBI)
Binding site70-73GTP (UniProtKB | ChEBI)
Binding site129-132GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular ComponentCOPII vesicle coat
Cellular Componentendoplasmic reticulum exit site
Cellular Componentendoplasmic reticulum membrane
Cellular ComponentGolgi membrane
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Biological Processendoplasmic reticulum to Golgi vesicle-mediated transport
Biological Processintracellular protein transport
Biological Processmembrane organization
Biological Processpositive regulation of protein exit from endoplasmic reticulum
Biological Processregulation of COPII vesicle coating
Biological Processvesicle organization

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Gene names

    • Name
      SAR1
    • Ordered locus names
      CNB03430

Organism names

Accessions

  • Primary accession
    P0CR30
  • Secondary accessions
    • Q55XY7
    • Q5KM05

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasmic vesicle, COPII-coated vesicle membrane
; Peripheral membrane protein
Endoplasmic reticulum membrane
; Peripheral membrane protein
Golgi apparatus membrane
; Peripheral membrane protein

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002955131-189Small COPII coat GTPase SAR1

Proteomic databases

Interaction

Subunit

COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the small GTPase superfamily. SAR1 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    189
  • Mass (Da)
    21,382
  • Last updated
    2011-06-28 v1
  • Checksum
    2FD8A8A2FD050098
MFIINWFWDVLASLGLMNKSAKLLFLGLDNAGKTTLLHMLKNDRLATLQPTLHPTSEELAIGNVKFTTYDLGGHIQARRLWRDYFPEVDGIVFLVDSADAERFAESKAELDSLLSIESLAQVPFLILGNKIDAYGAVSEEQLRHELGLYQTTGKGKIPLRDIRPIEVFMCSVVMRQGYGEGFRWLSQYI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE017342
EMBL· GenBank· DDBJ
AAW41610.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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