P0CN86 · TRPG_CRYNJ

Function

function

Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.
Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site58-60L-glutamine (UniProtKB | ChEBI)
Active site86Nucleophile; for GATase activity
Binding site136-137L-glutamine (UniProtKB | ChEBI)
Active site176For GATase activity
Active site178For GATase activity

GO annotations

AspectTerm
Molecular Functionanthranilate synthase activity
Molecular Functionindole-3-glycerol-phosphate lyase activity
Molecular Functionindole-3-glycerol-phosphate synthase activity
Molecular Functionphosphoribosylanthranilate isomerase activity
Biological Processglutamine metabolic process
Biological Processtryptophan biosynthetic process

Keywords

Enzyme and pathway databases

    • UPA00035UER00040
    • UPA00035UER00042
    • UPA00035UER00043

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional tryptophan biosynthesis protein

Including 3 domains:

  • Recommended name
    Anthranilate synthase component 2
  • EC number
  • Short names
    AS
  • Alternative names
    • Anthranilate synthase, glutamine amidotransferase component
  • Recommended name
    Indole-3-glycerol phosphate synthase
  • EC number
  • Short names
    IGPS
  • Recommended name
    N-(5'-phosphoribosyl)anthranilate isomerase
  • EC number
  • Short names
    PRAI

Gene names

    • Name
      TRP1
    • Ordered locus names
      CNI00560

Organism names

Accessions

  • Primary accession
    P0CN86
  • Secondary accessions
    • Q55NN6
    • Q5KC22

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000568571-752Multifunctional tryptophan biosynthesis protein

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain3-202Glutamine amidotransferase type-1
Region231-495Indole-3-glycerol phosphate synthase
Region509-752N-(5'-phosphoribosyl)anthranilate isomerase

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    752
  • Mass (Da)
    80,473
  • Last updated
    2011-06-28 v1
  • Checksum
    BE85651BED85BBE5
MGFTLLIDNYDSFTWNIYADLASVGGNPYVVRNDKITLKEIEGMFSDGELERIVISPGPGHPRTDSGVSRDVIAWGMGKLPILGVCMGLECIVDLLGGEIAYAGEIKHGKTSLVQHDSIGVFHNLPQFLSSTRYHSLSAQIQSLPSVLQVTSTTKESGVIMGVRHRTYTVEAVQYHPESCMSEGGRGLMANFIQMKGGKWGGENAWCGVPAEGEEEQPKAKTNGAPSLPTILNRIHAQRLLDVEQAEKVPATSPANVSTSLSLYASPPLINFRDRMVSTPHTAVMAEIKRASPSKGDIAPTASAPEQALKYALAGASVISVLTEPTWFKGSLLDMLAVRNAVDSLPNRPAILRKDFVLSKYMIDEARLYGADTVLLIVAMLEPQQLKELYDYSVSLGMEPLVEVNNPTELSLALEIGSKVIGVNNRNLHDFNVDMSTTSRVNAALNGRDVVLCALSGISSHEDVEKYVKEGVKGVLVGEALMRASDTKAFLRSLIGLPPLEVVPKSRPLVKICGIRSTDDAKLAISAGADLLGVILVPGTKRCISTSTAREISALVQSARSQSSSKPLEPSLSSPWFTTQSDLLSSRRKPLLVGVFQNQSLSDILSAVEEIGLDLVQLHGDEPQAWAKFIPVPVVKVFRVSPEGIVRGGEFRRPGLNQAILLDAGGVSGGGGEGKAFPWEHAKRLIQSGEVGSEGHMPLPVILAGGLTPENVGQAIEQAGEGVWCVDVSSGVEGEGGKVKEKVEAFVKAVRG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE017349
EMBL· GenBank· DDBJ
AAW45488.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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