P0CM99 · CWC25_CRYNB
- ProteinPre-mRNA-splicing factor CWC25
- GeneCWC25
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids434 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Involved in pre-mRNA splicing.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | U2-type spliceosomal complex | |
Biological Process | mRNA processing | |
Biological Process | RNA splicing |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended namePre-mRNA-splicing factor CWC25
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Tremellomycetes > Tremellales > Cryptococcaceae > Cryptococcus > Cryptococcus neoformans species complex
Accessions
- Primary accessionP0CM99
- Secondary accessions
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000410053 | 1-434 | Pre-mRNA-splicing factor CWC25 | |||
Sequence: MGGGDLNMKKSWHPVLLVNQERVWKAEKVANEEKKMLAQLRKEREEERQLEELHRLQEASTGKKRVEKLDWMYAAPSTEGGALGGARIGERDMEEYLLGKKRVDEVLGQGDKNIGAASREFIALQNANTARDTAAKIREDPLLAIKKQEQAALAALMNRPDIRKQLRAAKKAKETKGREGESKEERKARKRAEKEERRKSKHRYHDSRSPPSDYYDDRDHRRHRDSYDSQDRENRRTYRDRSDRSRTRSESPKREKKEKDYSNRDRDYRRRNDTTRGSFDESPRKGGGNRWGSHGPDGYRRSDHRDDGFRERQRGDRIPPPRHLSYNHSTPDVRPSSPPSSSAAPVNRNTSTLEDQRAARLAAMSASADELYSSRSKSLAARAEEERREQEKDEKMRQKYGKEQASANFFSQQSQLGLGEALQRRGGKGLLKDI |
Interaction
Subunit
Associated with the spliceosome.
Structure
Family & Domains
Features
Showing features for coiled coil, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 20-61 | |||||
Sequence: QERVWKAEKVANEEKKMLAQLRKEREEERQLEELHRLQEAST | ||||||
Region | 43-63 | Disordered | ||||
Sequence: EREEERQLEELHRLQEASTGK | ||||||
Region | 156-412 | Disordered | ||||
Sequence: LMNRPDIRKQLRAAKKAKETKGREGESKEERKARKRAEKEERRKSKHRYHDSRSPPSDYYDDRDHRRHRDSYDSQDRENRRTYRDRSDRSRTRSESPKREKKEKDYSNRDRDYRRRNDTTRGSFDESPRKGGGNRWGSHGPDGYRRSDHRDDGFRERQRGDRIPPPRHLSYNHSTPDVRPSSPPSSSAAPVNRNTSTLEDQRAARLAAMSASADELYSSRSKSLAARAEEERREQEKDEKMRQKYGKEQASANFFSQ | ||||||
Compositional bias | 163-192 | Basic and acidic residues | ||||
Sequence: RKQLRAAKKAKETKGREGESKEERKARKRA | ||||||
Compositional bias | 199-280 | Basic and acidic residues | ||||
Sequence: KSKHRYHDSRSPPSDYYDDRDHRRHRDSYDSQDRENRRTYRDRSDRSRTRSESPKREKKEKDYSNRDRDYRRRNDTTRGSFD | ||||||
Compositional bias | 296-321 | Basic and acidic residues | ||||
Sequence: PDGYRRSDHRDDGFRERQRGDRIPPP | ||||||
Compositional bias | 329-356 | Polar residues | ||||
Sequence: STPDVRPSSPPSSSAAPVNRNTSTLEDQ | ||||||
Compositional bias | 379-401 | Basic and acidic residues | ||||
Sequence: LAARAEEERREQEKDEKMRQKYG |
Sequence similarities
Belongs to the CWC25 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length434
- Mass (Da)50,153
- Last updated2011-06-28 v1
- ChecksumD5534B3F7F9625BB
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 163-192 | Basic and acidic residues | ||||
Sequence: RKQLRAAKKAKETKGREGESKEERKARKRA | ||||||
Compositional bias | 199-280 | Basic and acidic residues | ||||
Sequence: KSKHRYHDSRSPPSDYYDDRDHRRHRDSYDSQDRENRRTYRDRSDRSRTRSESPKREKKEKDYSNRDRDYRRRNDTTRGSFD | ||||||
Compositional bias | 296-321 | Basic and acidic residues | ||||
Sequence: PDGYRRSDHRDDGFRERQRGDRIPPP | ||||||
Compositional bias | 329-356 | Polar residues | ||||
Sequence: STPDVRPSSPPSSSAAPVNRNTSTLEDQ | ||||||
Compositional bias | 379-401 | Basic and acidic residues | ||||
Sequence: LAARAEEERREQEKDEKMRQKYG |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAEY01000021 EMBL· GenBank· DDBJ | EAL21040.1 EMBL· GenBank· DDBJ | Genomic DNA |