P0CM30 · ATG2_CRYNJ

Function

function

Lipid transfer protein required for autophagosome completion and peroxisome degradation. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion. ATG2 binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, using basic residues in its N-terminal region (NR) and to the expanding edge of the IM through its C-terminal region. The latter binding is assisted by an ATG18-PtdIns3P interaction. ATG2 then extracts phospholipids from the membrane source using its NR and transfers them to ATG9 to the IM through its predicted beta-sheet-rich structure for membrane expansion.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentphagophore
Cellular Componentphagophore assembly site
Cellular Componentphagophore assembly site membrane
Molecular Functionphosphatidylinositol-3-phosphate binding
Molecular Functionprotein-membrane adaptor activity
Biological Processautophagosome assembly
Biological Processautophagy of mitochondrion
Biological Processautophagy of peroxisome
Biological Processglycophagy
Biological Processlipid transport
Biological Processpiecemeal microautophagy of the nucleus
Biological Processprotein transport
Biological Processreticulophagy

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Autophagy-related protein 2

Gene names

    • Name
      ATG2
    • Ordered locus names
      CNB00700

Organism names

Accessions

  • Primary accession
    P0CM30
  • Secondary accessions
    • Q55X62
    • Q5KMS0

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002158291-1958

Proteomic databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain30-121Chorein N-terminal
Region286-319Disordered
Compositional bias291-319Polar residues
Compositional bias360-379Polar residues
Region360-412Disordered
Compositional bias385-399Basic and acidic residues

Sequence similarities

Belongs to the ATG2 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,958
  • Mass (Da)
    215,295
  • Last updated
    2024-05-29 v2
  • Checksum
    C6CE5A912620A8EA
MFSLPSFLTTFSFTLPSLPSISLPANIQRRFLSYVLKRTLGRFVSHQALDAERIQAQVSEGWVEIENLEIECSEINNYIPPPLPLSLTSGTINKLTAKLPFPNLWSDPLQVSLDTLTLDFTLSSPSPLSRGRAATRPEHHDLAESVTSAADDFLHHELDAYEEKELEGSIRQSLILSQTDPFISDVPGGFPLGSPGEISPGRPLPANMESTTVLAGMVERILARLEFRVEKIKIRLVIEDEEDVVELTVGRIRYADESEAQTNDDGKSTTRAIRISNISLDIVPSQRKPPSLVIPQRQSLEPSVSSSTSTASTSSGNDYSDMFMSQAVVDLRQSLLTPEQISEPANEQTVHESNMFYSALSQPNESEPGASTGIKRSGISQNPKLADEIEEERSRSETPTPETKPQPSGIPVLSFGQEDVVLHMRTTRPLISAGHQTSFNDNKPTVEMNITIGTITTVLLPSHLKLFISALQTLQALCQKDDVPAAKDKPAQSTSPQTRLTATTKLKAFYVSLVYDLSAETSLNLHSTMASHLTRPTNPIPYPHLRFRLDTLVASYQSPGHSNPSRPAFTRPTPNMSTANLRRKSSGHARFGSLPSNLTVNVGDISLFEWMGEGMIAPVILFDPGLKHQYDLPSAPPHKGQAGFPECECRDWREEKKTGSEKAWRVRPRGRGILKGGARATTEDEGPVVHVRQDLGSDSAAVINLQSLHVFVDLSLIERLLPLLRSVTPLIHPPEPTPAWLQSVPSQSISEEITPESIISSLSAPPPTARGKKMKADIRCDLVRLSVRCPAPPPEPAERQIGDGRQLRSGIVFVDVHGLKSRFMDTSRTGTRPASSEVANVEFEQTLIFFASVSQHYAYPFLIFAPLSPEPGEEDIPLLPSISLSSFPQASSLPASSIAKTTLVTCKMPAIRASVHHPTVTGLQYFADDVTRWLDVAFADGSAKPRDELKMIGSRFFGGSKGSEASSEIDEPYDVEEVAAGMKVEIEISEIDMGLYVPRLDASGERVFSFKANDLGVRMETHPEENETALELSIMDLDFSDVSSTPLRILGRTTPFTLTSHQAPVVYLRFVSSTDLRTTLKESNISVALSHFTFAVHKEIAWLHEIAQFAKPPKGVFENLSPTDLTRLSINLSSASFLLVPPNLPGSIVILVREVEGKTEIPKGATDSVLEVGMSGLGALAVEGESGPLEVSSDLADVWKKAGYAQLAEVMVLELRLMRELVAAGEVSLDITQAQFKVTACADSLATFAEIATDFGRLFPNKKEEHVKLPSMGQSINVFDSLDENAFNLLPEIVSHSDTDMIEDDLPHNLDYLDHATRISKHYPSMDRTTGENLRAWHTPEEGLEEGEWENGESGETIRAFGGEIEEEEGYWEGLPILNDVYSADQKPGKIHIRVLDASLKIFLHDGYDWPRTRKAIEDEVRAVRRRLERIRQLLASGQKADESIENATSSVLFNSIYIGLEQKGEMGLSTMGMGKMDEKALMAAIDEELDGMETESGSSWQTLPAGVGAGPSAVHQAHKKTRLKGKRLVRSKKAQIEITLSGIKTDVDLYPTEESTSSRVHFTAKEMEILDHIKTSTWKKFLTEMKADNRGNIRETDADMLRIELVGVRLKEDEEELRLRAKILPLRLHVDQDALDFLKRFFSFKAPPMTSARPLAQHTTSSTPDLYFQHVEIFPIQLKLDYKPKRVDFRALREGKTIELMNFFHFEGAEMTLRHITLSGITGLERLGTTLQDLWTPDVKANQLADVISGVSPIRSMVNVGSGVADLILLPIEQYRKDGRIAKGVQRGTNSFVKSTALEVMKLGARLATGTQVILERAEGVLGGKSGEDVVGQVQGLSTNAFGVDSGMLEGGSSSEDEQEAISRYADQPESMKEGVQAAYKSLSKNVNAAAQTILAVPMEVYERSGDDGPLKAVIRAVPIAVLKPMIGTTEAVSKTLLGMRNSLDPSARRELDDKYK

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias291-319Polar residues
Compositional bias360-379Polar residues
Compositional bias385-399Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE017342
EMBL· GenBank· DDBJ
AAW41772.2
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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